8PYW

Crystal structure of the human Nucleoside-diphosphate kinase B domain bound to compound diphosphate form of AT-9052-Sp.

Summary for 8PYW

Entry DOI	10.2210/pdb8pyw/pdb
Descriptor	Nucleoside diphosphate kinase B, GLYCEROL, [[(2R,3R,4R,5R)-5-(2-azanyl-6-oxidanylidene-1H-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methoxy-sulfanyl-phosphoryl] dihydrogen phosphate, ... (4 entities in total)
Functional Keywords	transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	6
Total formula weight	106627.46
Authors	Feracci, M.,Chazot, A. (deposition date: 2023-07-26, release date: 2023-12-27, Last modification date: 2024-02-21)
Primary citation	Shannon, A.,Chazot, A.,Feracci, M.,Falcou, C.,Fattorini, V.,Selisko, B.,Good, S.,Moussa, A.,Sommadossi, J.P.,Ferron, F.,Alvarez, K.,Canard, B. An exonuclease-resistant chain-terminating nucleotide analogue targeting the SARS-CoV-2 replicase complex. Nucleic Acids Res., 52:1325-1340, 2024 Cited by PubMed: 38096103 DOI: 10.1093/nar/gkad1194 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.553 Å)

Structure validation