2QEQ

Crystal structure of kunjin virus ns3 helicase

Summary for 2QEQ

• Entry DOI: 10.2210/pdb2qeq/pdb
• Descriptor: Flavivirin protease NS3 catalytic subunit (1 entity in total)
• Functional Keywords: helicase; flavivirus, hydrolase
• Biological source: Kunjin virus (STRAIN MRM61C)
• Cellular location: Capsid protein C: Virion (Potential). Peptide pr: Secreted (By similarity). Small envelope protein M: Virion membrane; Multi-pass membrane protein (By similarity). Envelope protein E: Virion membrane; Multi- pass membrane protein (By similarity). Non-structural protein 1: Secreted. Non-structural protein 2A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity): P14335
• Total number of polymer chains: 2
• Total formula weight: 98022.99

Authors

Milani, M.,Mastrangelo, E.,Bolognesi, M. (deposition date: 2007-06-26, release date: 2007-08-14, Last modification date: 2023-08-30)

• Primary citation: Mastrangelo, E.,Milani, M.,Bollati, M.,Selisko, B.,Peyrane, F.,Pandini, V.,Sorrentino, G.,Canard, B.,Konarev, P.V.,Svergun, D.I.,de Lamballerie, X.,Coutard, B.,Khromykh, A.A.,Bolognesi, M.; Crystal structure and activity of Kunjin virus NS3 helicase; protease and helicase domain assembly in the full length NS3 protein; J.Mol.Biol., 372:444-455, 2007; PubMed: 17658551; DOI: 10.1016/j.jmb.2007.06.055

Experimental method

X-RAY DIFFRACTION (3.1 Å)