1R6A

Structure of the dengue virus 2'O methyltransferase in complex with s-adenosyl homocysteine and ribavirin 5' triphosphate

Summary for 1R6A

Related1L9K
DescriptorGenome polyprotein, SULFATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ... (5 entities in total)
Functional Keywordsribavirin 5'-triphosphate, dengue virus, 2'o methyltransferase, transferase
Biological sourceDengue virus 2 Puerto Rico/PR159-S1/1969
Cellular locationCapsid protein C: Virion (Potential). Peptide pr: Secreted (By similarity). Small envelope protein M: Virion membrane; Multi-pass membrane protein (By similarity). Envelope protein E: Virion membrane; Multi- pass membrane protein (By similarity). Non-structural protein 1: Secreted. Non-structural protein 2A-alpha: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Non-structural protein 2A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity) P12823
Total number of polymer chains1
Total molecular weight34526.71
Authors
Benarroch, D.,Egloff, M.P.,Mulard, L.,Romette, J.L.,Canard, B. (deposition date: 2003-10-15, release date: 2004-09-21, Last modification date: 2011-07-13)
Primary citation
Benarroch, D.,Egloff, M.P.,Mulard, L.,Guerreiro, C.,Romette, J.L.,Canard, B.
A structural basis for the inhibition of the NS5 dengue virus mRNA 2'-O-methyltransferase domain by ribavirin 5'-triphosphate.
J.Biol.Chem., 279:35638-35643, 2004
PubMed: 15152003 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M400460200
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliers0.286231.9%4.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution