1R6A
Structure of the dengue virus 2'O methyltransferase in complex with s-adenosyl homocysteine and ribavirin 5' triphosphate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Genome polyprotein | polymer | 295 | 33145.7 | 1 | UniProt (P12823) | Dengue virus 2 Puerto Rico/PR159-S1/1969 | NS5 |
| 2 | B, C, D, E, F... (A) | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
| 3 | I (A) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) PubChem (193) PubChem (13792) PubChem (189149) PubChem (439155) PubChem (5284331) PubChem (71170554) PubChem (13231890) PubChem (16760024) PubChem (25210495) PubChem (44361184) PubChem (177678424) PubChem (46936206) PubChem (21125603) PubChem (25203782) PubChem (52224400) PubChem (50989525) PubChem (51380914) PubChem (52224398) PubChem (6419189) PubChem (57544532) PubChem (59046843) PubChem (59170628) PubChem (164157219) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (118374891) PubChem (118560068) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525) | |||
| 4 | J (A) | RIBAVIRIN MONOPHOSPHATE | non-polymer | 324.2 | 1 | Chemie (RVP) PubChem (100252) PubChem (321727) PubChem (5748447) PubChem (29986967) PubChem (45040365) PubChem (59034322) PubChem (59895799) PubChem (91345184) PubChem (59892659) PubChem (70536421) PubChem (90788486) PubChem (92145095) PubChem (92261915) PubChem (92261916) PubChem (92261917) PubChem (146830266) PubChem (172677295) | |||
| 5 | K (A) | water | water | 18.0 | 66 | Chemie (HOH) |
Sequence modifications
A: 4 - 296 (UniProt: P12823)
| PDB | External Database | Details |
|---|---|---|
| Gly 2 | - | cloning artifact |
| Ser 3 | - | cloning artifact |
| Ile 135 | Val 2623 | conflict |
| Arg 139 | Lys 2627 | conflict |
| Ser 173 | Asn 2661 | conflict |
| Lys 193 | Arg 2681 | conflict |
| Ala 196 | Thr 2684 | conflict |
| His 201 | Tyr 2689 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33145.7 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1381.0 | |
| All* | Total formula weight | 34526.7 |
