1R6A
Structure of the dengue virus 2'O methyltransferase in complex with s-adenosyl homocysteine and ribavirin 5' triphosphate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Genome polyprotein | polymer | 295 | 33145.7 | 1 | UniProt (P12823) Pfam (PF01728) | Dengue virus 2 Puerto Rico/PR159-S1/1969 | NS5 |
| 2 | B, C, D, E, F... (A) | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
| 3 | I (A) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) | |||
| 4 | J (A) | RIBAVIRIN MONOPHOSPHATE | non-polymer | 324.2 | 1 | Chemie (RVP) | |||
| 5 | K (A) | water | water | 18.0 | 66 | Chemie (HOH) |
Sequence modifications
A: 4 - 296 (UniProt: P12823)
| PDB | External Database | Details |
|---|---|---|
| Gly 2 | - | cloning artifact |
| Ser 3 | - | cloning artifact |
| Ile 135 | Val 2623 | conflict |
| Arg 139 | Lys 2627 | conflict |
| Ser 173 | Asn 2661 | conflict |
| Lys 193 | Arg 2681 | conflict |
| Ala 196 | Thr 2684 | conflict |
| His 201 | Tyr 2689 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33145.7 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1381.0 | |
| All* | Total formula weight | 34526.7 |
