4NZ0

The EMCV 3Dpol structure at 2.8A resolution

Summary for 4NZ0

• Entry DOI: 10.2210/pdb4nz0/pdb
• Related: 1U09 4nyz
• Descriptor: Genome polyprotein, GLYCEROL, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: encephalomyocarditis virus, close right hand, rna dependent rna polymerase, transferase
• Biological source: Mengo virus
• Cellular location: Protein 2A: Host nucleus . Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 2C: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3A: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3B: Virion . Protease 3C: Host cytoplasm . RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side : P12296
• Total number of polymer chains: 6
• Total formula weight: 314239.23

Authors

Vives-adrian, L.,Ferrer-orta, C.,Verdaguer, N. (deposition date: 2013-12-11, release date: 2014-03-19, Last modification date: 2023-11-08)

• Primary citation: Vives-Adrian, L.,Lujan, C.,Oliva, B.,van der Linden, L.,Selisko, B.,Coutard, B.,Canard, B.,van Kuppeveld, F.J.,Ferrer-Orta, C.,Verdaguer, N.; The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site; J.Virol., 88:5595-5607, 2014; PubMed: 24600002; DOI: 10.1128/JVI.03502-13

Experimental method

X-RAY DIFFRACTION (2.8 Å)