2HCS

Crystal structure of RNA dependant RNA polymerase domain of West Nile virus

Summary for 2HCS

Related2HCN
DescriptorRNA-directed RNA polymerase (NS5), ZINC ION (3 entities in total)
Functional Keywordswest-nile virus rna polymerase, structural genomics, marseilles structural genomics program @ afmb, msgp, vizier, viral enzymes involved in replication, transferase
Biological sourceKunjin virus
Cellular locationCapsid protein C: Virion (Potential). Peptide pr: Secreted (By similarity). Small envelope protein M: Virion membrane; Multi-pass membrane protein (By similarity). Envelope protein E: Virion membrane; Multi- pass membrane protein (By similarity). Non-structural protein 1: Secreted. Non-structural protein 2A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity) P14335
Total number of polymer chains1
Total molecular weight68462.47
Authors
Egloff, M.P.,Malet, H.,Marseilles Structural Genomics Program @ AFMB (MSGP) (deposition date: 2006-06-18, release date: 2007-02-06, Last modification date: 2011-07-13)
Primary citation
Malet, H.,Egloff, M.P.,Selisko, B.,Butcher, R.E.,Wright, P.J.,Roberts, M.,Gruez, A.,Sulzenbacher, G.,Vonrhein, C.,Bricogne, G.,Mackenzie, J.M.,Khromykh, A.A.,Davidson, A.D.,Canard, B.
Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5
J.Biol.Chem., 282:10678-10689, 2007
PubMed: 17287213 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M607273200
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers111.7%14.7%19.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution