4KM5
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![BU of 4km5 by Molmil](/molmil-images/mine/4km5) | X-ray crystal structure of human cyclic GMP-AMP synthase (cGAS) | 分子名称: | Cyclic GMP-AMP synthase, ZINC ION | 著者 | Kranzusch, P.J, Lee, A.S.Y, Berger, J.M, Doudna, J.A. | 登録日 | 2013-05-08 | 公開日 | 2013-05-29 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.499 Å) | 主引用文献 | Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity. Cell Rep, 3, 2013
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4TXY
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![BU of 4txy by Molmil](/molmil-images/mine/4txy) | Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase, a prokaryotic cGAS homolog | 分子名称: | Cyclic AMP-GMP synthase, MAGNESIUM ION | 著者 | Kranzusch, P.J, Lee, A.S.Y, Wilson, S.C, Solovykh, M.S, Vance, R.E, Berger, J.M, Doudna, J.A. | 登録日 | 2014-07-07 | 公開日 | 2014-08-13 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.0001 Å) | 主引用文献 | Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity. Cell, 158, 2014
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4TY0
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![BU of 4ty0 by Molmil](/molmil-images/mine/4ty0) | Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase in complex with linear intermediate 5' pppA(3',5')pG | 分子名称: | ACETATE ION, Cyclic AMP-GMP synthase, MAGNESIUM ION, ... | 著者 | Kranzusch, P.J, Lee, A.S.Y, Wilson, S.C, Solovykh, M.S, Vance, R.E, Berger, J.M, Doudna, J.A. | 登録日 | 2014-07-07 | 公開日 | 2014-08-13 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity. Cell, 158, 2014
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4TXZ
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![BU of 4txz by Molmil](/molmil-images/mine/4txz) | Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase in complex with nonhydrolyzable GTP | 分子名称: | Cyclic AMP-GMP synthase, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER | 著者 | Kranzusch, P.J, Lee, A.S.Y, Wilson, S.C, Solovykh, M.S, Vance, R.E, Berger, J.M, Doudna, J.A. | 登録日 | 2014-07-07 | 公開日 | 2014-08-13 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity. Cell, 158, 2014
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5CFN
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![BU of 5cfn by Molmil](/molmil-images/mine/5cfn) | Crystal structure of anemone STING (Nematostella vectensis) in complex with 3',3' c-di-AMP, c[A(3',5')pA(3',5')p] | 分子名称: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, Stimulator of Interferon Genes | 著者 | Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E. | 登録日 | 2015-07-08 | 公開日 | 2015-08-26 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling. Mol.Cell, 59, 2015
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5CFP
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![BU of 5cfp by Molmil](/molmil-images/mine/5cfp) | Crystal structure of anemone STING (Nematostella vectensis) 'humanized' F276K in complex with 3', 3' c-di-GMP, c[G(3', 5')pG(3', 5')p]' | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Stimulator of Interferon Genes | 著者 | Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E. | 登録日 | 2015-07-08 | 公開日 | 2015-08-26 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.066 Å) | 主引用文献 | Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling. Mol.Cell, 59, 2015
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5CFO
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![BU of 5cfo by Molmil](/molmil-images/mine/5cfo) | Crystal structure of anemone STING (Nematostella vectensis) in apo 'rotated' open conformation | 分子名称: | Stimulator of Interferon Genes | 著者 | Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E. | 登録日 | 2015-07-08 | 公開日 | 2015-08-26 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.102 Å) | 主引用文献 | Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling. Mol.Cell, 59, 2015
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5CFL
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![BU of 5cfl by Molmil](/molmil-images/mine/5cfl) | Crystal structure of anemone STING (Nematostella vectensis) in complex with 3', 3' c-di-GMP, c[G(3', 5')pG(3', 5')p] | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CITRATE ANION, Stimulator of Interferon Genes | 著者 | Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E. | 登録日 | 2015-07-08 | 公開日 | 2015-08-26 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.836 Å) | 主引用文献 | Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling. Mol.Cell, 59, 2015
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5CFR
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![BU of 5cfr by Molmil](/molmil-images/mine/5cfr) | Crystal structure of anemone STING (Nematostella vectensis) in apo 'unrotated' closed conformation | 分子名称: | CALCIUM ION, Stimulator of Interferon Genes | 著者 | Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E. | 登録日 | 2015-07-08 | 公開日 | 2015-08-26 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling. Mol.Cell, 59, 2015
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5CFM
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![BU of 5cfm by Molmil](/molmil-images/mine/5cfm) | Crystal structure of anemone STING (Nematostella vectensis) in complex with 3', 3' cGAMP, c[G(3', 5')pA(3', 5')p] | 分子名称: | 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, CITRATE ANION, Stimulator of Interferon Genes | 著者 | Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E. | 登録日 | 2015-07-08 | 公開日 | 2015-08-26 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.994 Å) | 主引用文献 | Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling. Mol.Cell, 59, 2015
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5CFQ
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![BU of 5cfq by Molmil](/molmil-images/mine/5cfq) | Crystal structure of anemone STING (Nematostella vectensis) in complex with 2',3' cGAMP, c[G(2',5')pA(3',5')p] | 分子名称: | SULFATE ION, Stimulator of Interferon Genes, cGAMP | 著者 | Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E. | 登録日 | 2015-07-08 | 公開日 | 2015-08-26 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.099 Å) | 主引用文献 | Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling. Mol.Cell, 59, 2015
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5K4C
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![BU of 5k4c by Molmil](/molmil-images/mine/5k4c) | Structure of eukaryotic translation initiation factor 3 subunit D (eIF3d) cap binding domain from Nasonia vitripennis, Crystal form 2 | 分子名称: | Eukaryotic translation initiation factor 3 subunit D, GLYCEROL | 著者 | Kranzusch, P.J, Lee, A.S.Y, Doudna, J.A, Cate, J.H.D. | 登録日 | 2016-05-20 | 公開日 | 2016-07-27 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.698 Å) | 主引用文献 | eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. Nature, 536, 2016
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5K4B
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![BU of 5k4b by Molmil](/molmil-images/mine/5k4b) | Structure of eukaryotic translation initiation factor 3 subunit D (eIF3d) cap binding domain from Nasonia vitripennis, Crystal form 1 | 分子名称: | CHLORIDE ION, Eukaryotic translation initiation factor 3 subunit D | 著者 | Kranzusch, P.J, Lee, A.S.Y, Doudna, J.A, Cate, J.H.D. | 登録日 | 2016-05-20 | 公開日 | 2016-07-27 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.399 Å) | 主引用文献 | eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. Nature, 536, 2016
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5K4D
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![BU of 5k4d by Molmil](/molmil-images/mine/5k4d) | Structure of eukaryotic translation initiation factor 3 subunit D (eIF3d) cap binding domain from Nasonia vitripennis, Crystal form 3 | 分子名称: | Eukaryotic translation initiation factor 3 subunit D | 著者 | Kranzusch, P.J, Lee, A.S.Y, Doudna, J.A, Cate, J.H.D. | 登録日 | 2016-05-20 | 公開日 | 2016-07-27 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. Nature, 536, 2016
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7UCW
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![BU of 7ucw by Molmil](/molmil-images/mine/7ucw) | Structure of mouse Decr1 in complex with 2'-5' oligoadenylate | 分子名称: | Decr1 protein, [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate | 著者 | Govande, A.A, Kranzusch, P.J. | 登録日 | 2022-03-17 | 公開日 | 2023-03-22 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | RNase L-activating 2'-5' oligoadenylates bind ABCF1, ABCF3 and Decr-1. J.Gen.Virol., 104, 2023
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6XB3
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![BU of 6xb3 by Molmil](/molmil-images/mine/6xb3) | |
6XB6
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![BU of 6xb6 by Molmil](/molmil-images/mine/6xb6) | |
6XB5
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![BU of 6xb5 by Molmil](/molmil-images/mine/6xb5) | |
6XB4
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![BU of 6xb4 by Molmil](/molmil-images/mine/6xb4) | |
7R65
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![BU of 7r65 by Molmil](/molmil-images/mine/7r65) | |
5I4A
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![BU of 5i4a by Molmil](/molmil-images/mine/5i4a) | X-ray crystal structure of Marinitoga piezophila Argonaute in complex with 5' OH guide RNA | 分子名称: | Argonaute protein, RNA (5'-R(*UP*AP*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*U)-3') | 著者 | Doxzen, K.W, Kaya, E, Knoll, K.R, Wilson, R.C, Strutt, S.C, Kranzusch, P.J, Doudna, J.A. | 登録日 | 2016-02-11 | 公開日 | 2016-03-30 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.949 Å) | 主引用文献 | A bacterial Argonaute with noncanonical guide RNA specificity. Proc.Natl.Acad.Sci.USA, 113, 2016
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8EFN
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![BU of 8efn by Molmil](/molmil-images/mine/8efn) | Structure of Sp-STING3 from Stylophora pistillata coral in complex with 3',3'-cGAMP | 分子名称: | 1,2-ETHANEDIOL, 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, Stimulator of interferon genes protein | 著者 | Li, Y, Slavik, K.M, Morehouse, B.R, Mears, K, Kranzusch, P.J. | 登録日 | 2022-09-08 | 公開日 | 2023-07-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | cGLRs are a diverse family of pattern recognition receptors in innate immunity. Cell, 186, 2023
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8EFM
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![BU of 8efm by Molmil](/molmil-images/mine/8efm) | Structure of coral STING receptor from Stylophora pistillata in complex with 2',3'-cGAMP | 分子名称: | SULFATE ION, Stimulator of interferon genes protein, cGAMP | 著者 | Li, Y, Slavik, K.M, Morehouse, B.R, Mears, K, Kranzusch, P.J. | 登録日 | 2022-09-08 | 公開日 | 2023-07-05 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | cGLRs are a diverse family of pattern recognition receptors in innate immunity. Cell, 186, 2023
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8DP6
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![BU of 8dp6 by Molmil](/molmil-images/mine/8dp6) | |
8DP7
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![BU of 8dp7 by Molmil](/molmil-images/mine/8dp7) | |