5CFN

Crystal structure of anemone STING (Nematostella vectensis) in complex with 3',3' c-di-AMP, c[A(3',5')pA(3',5')p]

Summary for 5CFN

• Entry DOI: 10.2210/pdb5cfn/pdb
• Related: 5CFL 5CFM 5CFO 5CFP 5CFQ 5CFR
• Descriptor: Stimulator of Interferon Genes, (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide (2 entities in total)
• Functional Keywords: sting, cyclic-dinucleotide binding domain, immune system
• Biological source: Nematostella vectensis (Starlet sea anemone)
• Total number of polymer chains: 2
• Total formula weight: 44768.27

Authors

Kranzusch, P.J.,Wilson, S.C.,Lee, A.S.Y.,Berger, J.M.,Doudna, J.A.,Vance, R.E. (deposition date: 2015-07-08, release date: 2015-08-26, Last modification date: 2024-03-06)

• Primary citation: Kranzusch, P.J.,Wilson, S.C.,Lee, A.S.,Berger, J.M.,Doudna, J.A.,Vance, R.E.; Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.; Mol.Cell, 59:891-903, 2015; PubMed: 26300263; DOI: 10.1016/j.molcel.2015.07.022

Experimental method

X-RAY DIFFRACTION (2.95 Å)