5CFM

Crystal structure of anemone STING (Nematostella vectensis) in complex with 3', 3' cGAMP, c[G(3', 5')pA(3', 5')p]

Summary for 5CFM

• Entry DOI: 10.2210/pdb5cfm/pdb
• Related: 5CFL 5CFN 5CFO 5CFP 5CFQ 5CFR
• Descriptor: Stimulator of Interferon Genes, 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, CITRATE ANION, ... (4 entities in total)
• Functional Keywords: sting, cyclic-dinucleotide binding domain, immune system
• Biological source: Nematostella vectensis (Starlet sea anemone)
• Total number of polymer chains: 2
• Total formula weight: 44882.26

Authors

Kranzusch, P.J.,Wilson, S.C.,Lee, A.S.Y.,Berger, J.M.,Doudna, J.A.,Vance, R.E. (deposition date: 2015-07-08, release date: 2015-08-26, Last modification date: 2024-03-06)

• Primary citation: Kranzusch, P.J.,Wilson, S.C.,Lee, A.S.,Berger, J.M.,Doudna, J.A.,Vance, R.E.; Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.; Mol.Cell, 59:891-903, 2015; PubMed: 26300263; DOI: 10.1016/j.molcel.2015.07.022

Experimental method

X-RAY DIFFRACTION (1.994 Å)