5CFM
Crystal structure of anemone STING (Nematostella vectensis) in complex with 3', 3' cGAMP, c[G(3', 5')pA(3', 5')p]
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002218 | biological_process | activation of innate immune response |
| A | 0032481 | biological_process | positive regulation of type I interferon production |
| B | 0002218 | biological_process | activation of innate immune response |
| B | 0032481 | biological_process | positive regulation of type I interferon production |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 36 |
| Details | binding site for residue 4BW A 401 |
| Chain | Residue |
| A | SER201 |
| A | GLU300 |
| A | THR303 |
| A | PRO304 |
| A | HOH506 |
| A | HOH522 |
| A | HOH524 |
| A | HOH529 |
| A | HOH541 |
| A | HOH550 |
| A | HOH556 |
| A | TYR202 |
| A | HOH571 |
| A | HOH583 |
| B | SER201 |
| B | TYR202 |
| B | GLY205 |
| B | TYR206 |
| B | ARG272 |
| B | VAL275 |
| B | PHE276 |
| B | ARG278 |
| A | GLY205 |
| B | TYR280 |
| B | GLU300 |
| B | THR303 |
| B | PRO304 |
| B | HOH504 |
| B | HOH523 |
| B | HOH526 |
| A | TYR206 |
| A | ARG272 |
| A | VAL275 |
| A | PHE276 |
| A | ARG278 |
| A | TYR280 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue FLC A 402 |
| Chain | Residue |
| A | GLN336 |
| A | LEU351 |
| A | VAL352 |
| A | THR353 |
| A | LYS367 |
| A | FLC403 |
| A | HOH511 |
| A | HOH544 |
| A | HOH567 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue FLC A 403 |
| Chain | Residue |
| A | TYR349 |
| A | GLU350 |
| A | LEU351 |
| A | FLC402 |
| A | HOH509 |
| A | HOH511 |
| A | HOH542 |
| A | HOH544 |
| A | HOH575 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue FLC B 401 |
| Chain | Residue |
| B | GLN336 |
| B | LEU351 |
| B | VAL352 |
| B | THR353 |
| B | LYS367 |
| B | HOH506 |
| B | HOH531 |
| B | HOH537 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue FLC B 402 |
| Chain | Residue |
| B | GLU350 |
| B | LEU351 |
| B | HOH506 |
| B | HOH521 |
| B | HOH537 |
| B | HOH563 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26300263","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5CFL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CFP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q86WV6","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"26300263","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5CFL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5CFP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26300263","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5CFQ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
