7R65

Crystal structure of a bacterial cyclic UMP synthase from Burkholderia cepacia LK29

Summary for 7R65

Entry DOI	10.2210/pdb7r65/pdb
Descriptor	Adenylate/guanylate cyclase (2 entities in total)
Functional Keywords	cyclic nucleotide, nucleotidyltransferase, bacteriophage-defense, pycsar, transferase
Biological source	Burkholderia cepacia (Pseudomonas cepacia)
Total number of polymer chains	4
Total formula weight	103078.06
Authors	Morehouse, B.R.,Kranzusch, P.J. (deposition date: 2021-06-22, release date: 2021-10-13, Last modification date: 2021-11-24)
Primary citation	Tal, N.,Morehouse, B.R.,Millman, A.,Stokar-Avihail, A.,Avraham, C.,Fedorenko, T.,Yirmiya, E.,Herbst, E.,Brandis, A.,Mehlman, T.,Oppenheimer-Shaanan, Y.,Keszei, A.F.A.,Shao, S.,Amitai, G.,Kranzusch, P.J.,Sorek, R. Cyclic CMP and cyclic UMP mediate bacterial immunity against phages. Cell, 184:5728-, 2021 Cited by PubMed: 34644530 DOI: 10.1016/j.cell.2021.09.031 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation