4TY0

Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase in complex with linear intermediate 5' pppA(3',5')pG

Summary for 4TY0

• Entry DOI: 10.2210/pdb4ty0/pdb
• Descriptor: Cyclic AMP-GMP synthase, MAGNESIUM ION, [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3-[[(2R,3S,4R,5R)-5-(2-azanyl-6-oxidanylidene-3H-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-4-oxidanyl-oxolan-2-yl]methoxy-[[oxidanyl(phosphonooxy)phosphoryl]methyl]phosphinic acid, ... (5 entities in total)
• Functional Keywords: nucleotidyl transferase, cyclic nucleotide synthase, cgas, transferase
• Biological source: Vibrio cholerae O1 biovar El Tor str. N16961
• Total number of polymer chains: 2
• Total formula weight: 95907.80

Authors

Kranzusch, P.J.,Lee, A.S.Y.,Wilson, S.C.,Solovykh, M.S.,Vance, R.E.,Berger, J.M.,Doudna, J.A. (deposition date: 2014-07-07, release date: 2014-08-13, Last modification date: 2023-12-27)

• Primary citation: Kranzusch, P.J.,Lee, A.S.,Wilson, S.C.,Solovykh, M.S.,Vance, R.E.,Berger, J.M.,Doudna, J.A.; Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity.; Cell, 158:1011-1021, 2014; PubMed: 25131990; DOI: 10.1016/j.cell.2014.07.028

Experimental method

X-RAY DIFFRACTION (1.8 Å)