4TXY

Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase, a prokaryotic cGAS homolog

Summary for 4TXY

Entry DOI	10.2210/pdb4txy/pdb
Descriptor	Cyclic AMP-GMP synthase, MAGNESIUM ION (2 entities in total)
Functional Keywords	nucleotidyl transferase, cyclic nucleotide synthase, cgas, transferase
Biological source	Vibrio cholerae O1 biovar El Tor str. N16961
Total number of polymer chains	2
Total formula weight	93981.23
Authors	Kranzusch, P.J.,Lee, A.S.Y.,Wilson, S.C.,Solovykh, M.S.,Vance, R.E.,Berger, J.M.,Doudna, J.A. (deposition date: 2014-07-07, release date: 2014-08-13, Last modification date: 2023-12-27)
Primary citation	Kranzusch, P.J.,Lee, A.S.,Wilson, S.C.,Solovykh, M.S.,Vance, R.E.,Berger, J.M.,Doudna, J.A. Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity. Cell, 158:1011-1021, 2014 Cited by PubMed: 25131990 DOI: 10.1016/j.cell.2014.07.028 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.0001 Å)

Structure validation