6EA9
Structure of VACV Poxin in post-reactive state with Gp[2'-5']Ap[3']
Summary for 6EA9
Entry DOI | 10.2210/pdb6ea9/pdb |
Descriptor | Protein B2, 2',5'-GpAp (3 entities in total) |
Functional Keywords | vaccina virus, nuclease, cgas, cgamp, poxvirus, innate immunity, hydrolase |
Biological source | Vaccinia virus WR (VACV) |
Total number of polymer chains | 5 |
Total formula weight | 127178.27 |
Authors | Eaglesham, J.B.,Kranzusch, P.J. (deposition date: 2018-08-02, release date: 2019-02-06, Last modification date: 2024-03-13) |
Primary citation | Eaglesham, J.B.,Pan, Y.,Kupper, T.S.,Kranzusch, P.J. Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling. Nature, 566:259-263, 2019 Cited by PubMed: 30728498DOI: 10.1038/s41586-019-0928-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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