6EA9
Structure of VACV Poxin in post-reactive state with Gp[2'-5']Ap[3']
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002218 | biological_process | activation of innate immune response |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0052170 | biological_process | symbiont-mediated suppression of host innate immune response |
| A | 0061507 | molecular_function | 2',3'-cyclic GMP-AMP binding |
| B | 0002218 | biological_process | activation of innate immune response |
| B | 0004518 | molecular_function | nuclease activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0030430 | cellular_component | host cell cytoplasm |
| B | 0052170 | biological_process | symbiont-mediated suppression of host innate immune response |
| B | 0061507 | molecular_function | 2',3'-cyclic GMP-AMP binding |
| C | 0002218 | biological_process | activation of innate immune response |
| C | 0004518 | molecular_function | nuclease activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0030430 | cellular_component | host cell cytoplasm |
| C | 0052170 | biological_process | symbiont-mediated suppression of host innate immune response |
| C | 0061507 | molecular_function | 2',3'-cyclic GMP-AMP binding |
| D | 0002218 | biological_process | activation of innate immune response |
| D | 0004518 | molecular_function | nuclease activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0030430 | cellular_component | host cell cytoplasm |
| D | 0052170 | biological_process | symbiont-mediated suppression of host innate immune response |
| D | 0061507 | molecular_function | 2',3'-cyclic GMP-AMP binding |
| E | 0002218 | biological_process | activation of innate immune response |
| E | 0004518 | molecular_function | nuclease activity |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0030430 | cellular_component | host cell cytoplasm |
| E | 0052170 | biological_process | symbiont-mediated suppression of host innate immune response |
| E | 0061507 | molecular_function | 2',3'-cyclic GMP-AMP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue 9BG A 301 |
| Chain | Residue |
| A | ALA129 |
| A | LYS186 |
| A | HOH419 |
| A | HOH422 |
| B | GLU14 |
| B | LEU16 |
| B | HIS17 |
| B | ALA18 |
| B | ALA27 |
| B | ARG60 |
| B | ILE105 |
| A | VAL130 |
| A | TYR138 |
| A | LYS142 |
| A | ALA145 |
| A | ASN149 |
| A | GLN169 |
| A | ARG182 |
| A | ARG184 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | binding site for residue 9BG B 301 |
| Chain | Residue |
| A | GLU14 |
| A | LEU16 |
| A | HIS17 |
| A | ALA18 |
| A | PHE19 |
| A | ALA27 |
| A | ARG60 |
| A | ILE105 |
| B | ALA129 |
| B | VAL130 |
| B | TYR138 |
| B | LYS142 |
| B | ALA145 |
| B | ASN149 |
| B | GLN169 |
| B | ARG182 |
| B | ARG184 |
| B | LYS186 |
| B | HOH417 |
| B | HOH424 |
| B | HOH432 |
| B | HOH434 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue 9BG C 301 |
| Chain | Residue |
| C | ALA129 |
| C | VAL130 |
| C | TYR138 |
| C | LYS142 |
| C | ALA145 |
| C | ASN149 |
| C | GLN169 |
| C | ARG182 |
| C | ARG184 |
| C | LYS186 |
| D | GLU14 |
| D | LEU16 |
| D | HIS17 |
| D | ALA18 |
| D | ALA27 |
| D | ARG60 |
| D | ILE105 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | binding site for residue 9BG D 301 |
| Chain | Residue |
| C | GLU14 |
| C | LEU16 |
| C | HIS17 |
| C | ALA18 |
| C | ALA27 |
| C | ARG60 |
| C | ILE105 |
| D | ALA129 |
| D | VAL130 |
| D | TYR138 |
| D | LYS142 |
| D | ASN149 |
| D | GLN169 |
| D | ARG182 |
| D | ARG184 |
| D | LYS186 |
| D | HOH402 |
| D | HOH407 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | binding site for residue 9BG E 301 |
| Chain | Residue |
| E | GLU14 |
| E | LEU16 |
| E | HIS17 |
| E | ALA18 |
| E | PHE19 |
| E | ALA27 |
| E | ARG60 |
| E | ALA129 |
| E | VAL130 |
| E | TYR138 |
| E | LYS142 |
| E | ALA145 |
| E | ASN149 |
| E | GLN169 |
| E | ARG182 |
| E | ARG184 |
| E | LYS186 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_04143","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"30728498","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Active site: {"description":"Shared with catalytic histidine of dimeric partner","evidences":[{"source":"HAMAP-Rule","id":"MF_04143","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"30728498","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | Active site: {"description":"Proton acceptor; shared with catalytic histidine of dimeric partner","evidences":[{"source":"HAMAP-Rule","id":"MF_04143","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"30728498","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 35 |
| Details | Site: {"description":"Substrate binding","evidences":[{"source":"HAMAP-Rule","id":"MF_04143","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"30728498","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
