5CFP
Crystal structure of anemone STING (Nematostella vectensis) 'humanized' F276K in complex with 3', 3' c-di-GMP, c[G(3', 5')pG(3', 5')p]'
Summary for 5CFP
Entry DOI | 10.2210/pdb5cfp/pdb |
Related | 5CFL 5CFM 5CFN 5CFO 5CFQ 5CFR |
Descriptor | Stimulator of Interferon Genes, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one) (3 entities in total) |
Functional Keywords | sting, cyclic-dinucleotide binding domain, immune system |
Biological source | Nematostella vectensis (Starlet sea anemone) |
Total number of polymer chains | 2 |
Total formula weight | 48316.15 |
Authors | Kranzusch, P.J.,Wilson, S.C.,Lee, A.S.Y.,Berger, J.M.,Doudna, J.A.,Vance, R.E. (deposition date: 2015-07-08, release date: 2015-08-26, Last modification date: 2024-03-06) |
Primary citation | Kranzusch, P.J.,Wilson, S.C.,Lee, A.S.,Berger, J.M.,Doudna, J.A.,Vance, R.E. Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling. Mol.Cell, 59:891-903, 2015 Cited by PubMed: 26300263DOI: 10.1016/j.molcel.2015.07.022 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.066 Å) |
Structure validation
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