5CFP
Crystal structure of anemone STING (Nematostella vectensis) 'humanized' F276K in complex with 3', 3' c-di-GMP, c[G(3', 5')pG(3', 5')p]'
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Stimulator of Interferon Genes | polymer | 202 | 23467.7 | 2 | UniProt (A7SLZ2) Pfam (PF15009) | Nematostella vectensis (Starlet sea anemone) | Predicted protein |
| 2 | C, D (A, B) | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one) | non-polymer | 690.4 | 2 | Chemie (C2E) PubChem (135440063) PubChem (135566344) PubChem (136437725) PubChem (136465801) PubChem (136503951) PubChem (146177770) PubChem (173716374) PubChem (174009991) PubChem (135566464) PubChem (135625254) PubChem (135867623) PubChem (135975628) PubChem (136177399) PubChem (136443483) PubChem (137221491) PubChem (137295286) PubChem (148921766) PubChem (148921769) PubChem (164708340) PubChem (168270823) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 241 | Chemie (HOH) |
Sequence modifications
A, B: 178 - 377 (UniProt: A7SLZ2)
| PDB | External Database | Details |
|---|---|---|
| Gly 176 | - | expression tag |
| Ser 177 | - | expression tag |
| Lys 276 | Phe 276 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 46935.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1380.8 | |
| All* | Total formula weight | 48316.2 |
