4KM5

X-ray crystal structure of human cyclic GMP-AMP synthase (cGAS)

Summary for 4KM5

Entry DOI	10.2210/pdb4km5/pdb
Descriptor	Cyclic GMP-AMP synthase, ZINC ION (3 entities in total)
Functional Keywords	dna sensor, innate immunity, zinc finger, nucleotidyl transferase, dna, cytoplasmic, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytosol . Note=(Microbial infection) Upon infection with virulent M: Q8N884
Total number of polymer chains	1
Total formula weight	43055.88
Authors	Kranzusch, P.J.,Lee, A.S.Y.,Berger, J.M.,Doudna, J.A. (deposition date: 2013-05-08, release date: 2013-05-29, Last modification date: 2024-02-28)
Primary citation	Kranzusch, P.J.,Lee, A.S.,Berger, J.M.,Doudna, J.A. Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity. Cell Rep, 3:1362-1368, 2013 Cited by PubMed: 23707061 DOI: 10.1016/j.celrep.2013.05.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.499 Å)

Structure validation