7PDZ
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![BU of 7pdz by Molmil](/molmil-images/mine/7pdz) | Structure of capping protein bound to the barbed end of a cytoplasmic actin filament | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | 著者 | Funk, J, Merino, F, Schacks, M, Rottner, K, Raunser, S, Bieling, P. | 登録日 | 2021-08-09 | 公開日 | 2021-09-01 | 最終更新日 | 2021-10-06 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks. Nat Commun, 12, 2021
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8RV2
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![BU of 8rv2 by Molmil](/molmil-images/mine/8rv2) | Structure of the formin INF2 bound to the barbed end of F-actin. | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | 著者 | Oosterheert, W, Boiero Sanders, M, Funk, J, Prumbaum, D, Raunser, S, Bieling, P. | 登録日 | 2024-01-31 | 公開日 | 2024-04-10 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | 主引用文献 | Molecular mechanism of actin filament elongation by formins. Science, 384, 2024
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8RTT
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![BU of 8rtt by Molmil](/molmil-images/mine/8rtt) | Structure of the formin Cdc12 bound to the barbed end of phalloidin-stabilized F-actin. | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | 著者 | Oosterheert, W, Boiero Sanders, M, Funk, J, Prumbaum, D, Raunser, S, Bieling, P. | 登録日 | 2024-01-29 | 公開日 | 2024-04-10 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.56 Å) | 主引用文献 | Molecular mechanism of actin filament elongation by formins. Science, 384, 2024
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8RU2
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![BU of 8ru2 by Molmil](/molmil-images/mine/8ru2) | Structure of the F-actin barbed end bound by formin mDia1 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | 著者 | Oosterheert, W, Boiero Sanders, M, Funk, J, Prumbaum, D, Raunser, S, Bieling, P. | 登録日 | 2024-01-29 | 公開日 | 2024-04-10 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | 主引用文献 | Molecular mechanism of actin filament elongation by formins. Science, 384, 2024
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8RTY
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![BU of 8rty by Molmil](/molmil-images/mine/8rty) | Structure of the F-actin barbed end bound by Cdc12 and profilin (ring complex) at a resolution of 6.3 Angstrom | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... | 著者 | Oosterheert, W, Boiero Sanders, M, Funk, J, Prumbaum, D, Raunser, S, Bieling, P. | 登録日 | 2024-01-29 | 公開日 | 2024-04-10 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (6.25 Å) | 主引用文献 | Molecular mechanism of actin filament elongation by formins. Science, 384, 2024
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8RU0
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![BU of 8ru0 by Molmil](/molmil-images/mine/8ru0) | Structure of the undecorated barbed end of F-actin. | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | 著者 | Oosterheert, W, Boiero Sanders, M, Funk, J, Prumbaum, D, Raunser, S, Bieling, P. | 登録日 | 2024-01-29 | 公開日 | 2024-04-10 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | Molecular mechanism of actin filament elongation by formins. Science, 384, 2024
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6FHL
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![BU of 6fhl by Molmil](/molmil-images/mine/6fhl) | Cryo-EM structure of F-actin in complex with ADP-Pi | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Merino, F, Pospich, S, Funk, J, Wagner, T, Kuellmer, F, Arndt, H.-D, Bieling, P, Raunser, S. | 登録日 | 2018-01-15 | 公開日 | 2018-06-13 | 最終更新日 | 2018-08-29 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural transitions of F-actin upon ATP hydrolysis at near-atomic resolution revealed by cryo-EM. Nat. Struct. Mol. Biol., 25, 2018
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7ZBQ
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![BU of 7zbq by Molmil](/molmil-images/mine/7zbq) | Structure of the ADP-ribosyltransferase TccC3HVR from Photorhabdus Luminescens | 分子名称: | TccC3 | 著者 | Lindemann, F, Belyy, A, Friedrich, D, Schmieder, P, Bardiaux, B, Roderer, D, Funk, J, Protze, J, Bieling, P, Oschkinat, H, Raunser, S. | 登録日 | 2022-03-24 | 公開日 | 2022-06-29 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | Mechanism of threonine ADP-ribosylation of F-actin by a Tc toxin. Nat Commun, 13, 2022
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5ONV
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![BU of 5onv by Molmil](/molmil-images/mine/5onv) | Cryo-EM structure of F-actin in complex with ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Merino, F, Pospich, S, Funk, J, Kuellmer, F, Arndt, H.-D, Bieling, P, Raunser, S. | 登録日 | 2017-08-04 | 公開日 | 2018-06-13 | 最終更新日 | 2019-11-06 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural transitions of F-actin upon ATP hydrolysis at near-atomic resolution revealed by cryo-EM. Nat. Struct. Mol. Biol., 25, 2018
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5OOD
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![BU of 5ood by Molmil](/molmil-images/mine/5ood) | Cryo-EM structure of jasplakinolide-stabilized F-actin in complex with ADP-Pi | 分子名称: | (4~{R},7~{R},10~{S},13~{S},15~{E},19~{S})-10-(4-azanylbutyl)-4-(4-hydroxyphenyl)-7-(1~{H}-indol-3-ylmethyl)-8,13,15,19-tetramethyl-1-oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetrone, ADENOSINE-5'-DIPHOSPHATE, Actin, ... | 著者 | Merino, F, Pospich, S, Funk, J, Kuellmer, F, Arndt, H.-D, Bieling, P, Raunser, S. | 登録日 | 2017-08-07 | 公開日 | 2018-06-13 | 最終更新日 | 2019-12-04 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural transitions of F-actin upon ATP hydrolysis at near-atomic resolution revealed by cryo-EM. Nat. Struct. Mol. Biol., 25, 2018
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5OOC
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![BU of 5ooc by Molmil](/molmil-images/mine/5ooc) | Cryo-EM structure of jasplakinolide-stabilized F-actin in complex with ADP | 分子名称: | (4~{R},7~{R},10~{S},13~{S},15~{E},19~{S})-10-(4-azanylbutyl)-4-(4-hydroxyphenyl)-7-(1~{H}-indol-3-ylmethyl)-8,13,15,19-tetramethyl-1-oxa-5,8,11-triazacyclononadec-15-ene-2,6,9,12-tetrone, ADENOSINE-5'-DIPHOSPHATE, Actin, ... | 著者 | Merino, F, Pospich, S, Funk, J, Kuellmer, F, Arndt, H.-D, Bieling, P, Raunser, S. | 登録日 | 2017-08-07 | 公開日 | 2018-06-13 | 最終更新日 | 2019-10-16 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural transitions of F-actin upon ATP hydrolysis at near-atomic resolution revealed by cryo-EM. Nat. Struct. Mol. Biol., 25, 2018
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5OOE
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![BU of 5ooe by Molmil](/molmil-images/mine/5ooe) | Cryo-EM structure of F-actin in complex with AppNHp (AMPPNP) | 分子名称: | Actin, alpha skeletal muscle, MAGNESIUM ION, ... | 著者 | Merino, F, Pospich, S, Funk, J, Kuellmer, F, Arndt, H.-D, Bieling, P, Raunser, S. | 登録日 | 2017-08-07 | 公開日 | 2018-06-13 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural transitions of F-actin upon ATP hydrolysis at near-atomic resolution revealed by cryo-EM. Nat. Struct. Mol. Biol., 25, 2018
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5OOF
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![BU of 5oof by Molmil](/molmil-images/mine/5oof) | Cryo-EM structure of F-actin in complex with ADP-BeFx | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Merino, F, Pospich, S, Funk, J, Kuellmer, F, Arndt, H.-D, Bieling, P, Raunser, S. | 登録日 | 2017-08-07 | 公開日 | 2018-06-13 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural transitions of F-actin upon ATP hydrolysis at near-atomic resolution revealed by cryo-EM. Nat. Struct. Mol. Biol., 25, 2018
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2WJ2
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![BU of 2wj2 by Molmil](/molmil-images/mine/2wj2) | 3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with 7-phenyl-1-(5-(pyridin-2-yl)oxazol-2-yl)heptan- 1-one, an alpha-ketooxazole | 分子名称: | 7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptane-1,1-diol, CHLORIDE ION, FATTY ACID AMIDE HYDROLASE 1 | 著者 | Mileni, M, Garfunkle, J, DeMartino, J.K, Cravatt, B.F, Boger, D.L, Stevens, R.C. | 登録日 | 2009-05-19 | 公開日 | 2009-09-15 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Binding and Inactivation Mechanism of a Humanized Fatty Acid Amide Hydrolase by Alpha-Ketoheterocycle Inhibitors Revealed from Cocrystal Structures. J.Am.Chem.Soc., 131, 2009
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2WJ1
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![BU of 2wj1 by Molmil](/molmil-images/mine/2wj1) | 3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with 7-phenyl-1-(4-(pyridin-2-yl)oxazol-2-yl)heptan- 1-one, an alpha-ketooxazole | 分子名称: | 7-phenyl-1-(4-pyridin-2-yl-1,3-oxazol-2-yl)heptane-1,1-diol, CHLORIDE ION, FATTY-ACID AMIDE HYDROLASE 1 | 著者 | Mileni, M, Garfunkle, J, DeMartino, J.K, Cravatt, B.F, Boger, D.L, Stevens, R.C. | 登録日 | 2009-05-19 | 公開日 | 2009-09-15 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Binding and Inactivation Mechanism of a Humanized Fatty Acid Amide Hydrolase by Alpha-Ketoheterocycle Inhibitors Revealed from Cocrystal Structures. J.Am.Chem.Soc., 131, 2009
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7Z7H
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![BU of 7z7h by Molmil](/molmil-images/mine/7z7h) | |
7Z7I
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![BU of 7z7i by Molmil](/molmil-images/mine/7z7i) | Structure of ADP-ribosylated F-actin | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5-DIPHOSPHORIBOSE, Actin, ... | 著者 | Belyy, A, Raunser, S. | 登録日 | 2022-03-15 | 公開日 | 2022-06-29 | 最終更新日 | 2023-03-15 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Mechanism of threonine ADP-ribosylation of F-actin by a Tc toxin. Nat Commun, 13, 2022
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7AHN
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![BU of 7ahn by Molmil](/molmil-images/mine/7ahn) | |
7AHQ
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![BU of 7ahq by Molmil](/molmil-images/mine/7ahq) | |
3K7F
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![BU of 3k7f by Molmil](/molmil-images/mine/3k7f) | Crystal Structure Analysis of a Phenhexyl/Oxazole/Carboxypyridine alpha-Ketoheterocycle Inhibitor Bound to a Humanized Variant of Fatty Acid Amide Hydrolase' | 分子名称: | 6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid, CHLORIDE ION, Fatty-acid amide hydrolase 1, ... | 著者 | Mileni, M, Stevens, R.C, Boger, D.L. | 登録日 | 2009-10-13 | 公開日 | 2009-12-01 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase. J.Med.Chem., 53, 2010
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3K84
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![BU of 3k84 by Molmil](/molmil-images/mine/3k84) | Crystal Structure Analysis of a Oleyl/Oxadiazole/pyridine Inhibitor Bound to a Humanized Variant of Fatty Acid Amide Hydrolase | 分子名称: | (9Z)-1-(5-pyridin-2-yl-1,3,4-oxadiazol-2-yl)octadec-9-en-1-one, CHLORIDE ION, Fatty-acid amide hydrolase 1 | 著者 | Mileni, M, Stevens, R.C, Boger, D.L. | 登録日 | 2009-10-13 | 公開日 | 2009-12-01 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase. J.Med.Chem., 53, 2010
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3K83
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![BU of 3k83 by Molmil](/molmil-images/mine/3k83) | Crystal Structure Analysis of a Biphenyl/Oxazole/Carboxypyridine alpha-ketoheterocycle Inhibitor Bound to a Humanized Variant of Fatty Acid Amide Hydrolase | 分子名称: | 1-DODECANOL, 6-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid, CHLORIDE ION, ... | 著者 | Mileni, M, Stevens, R.C, Boger, D.L. | 登録日 | 2009-10-13 | 公開日 | 2009-12-01 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.251 Å) | 主引用文献 | X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase. J.Med.Chem., 53, 2010
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3PR0
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![BU of 3pr0 by Molmil](/molmil-images/mine/3pr0) | Crystal Structure of a Covalently Bound alpha-Ketoheterocycle Inhibitor (Phenhexyl/Oxadiazole/Pyridine) to a Humanized Variant of Fatty Acid Amide Hydrolase | 分子名称: | 7-phenyl-1-[5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl]heptane-1,1-diol, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Mileni, M, Han, G.W, Boger, D.L, Stevens, R.C. | 登録日 | 2010-11-29 | 公開日 | 2011-11-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent alpha-ketoheterocycle inhibitor of fatty acid amide hydrolase. J.Am.Chem.Soc., 133, 2011
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3PPM
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![BU of 3ppm by Molmil](/molmil-images/mine/3ppm) | Crystal Structure of a Noncovalently Bound alpha-Ketoheterocycle Inhibitor (Phenhexyl/Oxadiazole/Pyridine) to a Humanized Variant of Fatty Acid Amide Hydrolase | 分子名称: | 1-DODECANOL, 7-phenyl-1-[5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl]heptan-1-one, CHLORIDE ION, ... | 著者 | Mileni, M, Han, G.W, Boger, D.L, Stevens, R.C. | 登録日 | 2010-11-24 | 公開日 | 2011-11-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent alpha-ketoheterocycle inhibitor of fatty acid amide hydrolase. J.Am.Chem.Soc., 133, 2011
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