2WJ2

3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with 7-phenyl-1-(5-(pyridin-2-yl)oxazol-2-yl)heptan- 1-one, an alpha-ketooxazole

Summary for 2WJ2

Entry DOI	10.2210/pdb2wj2/pdb
Related	1MT5 2VYA 2WAP 2WJ1
Descriptor	FATTY ACID AMIDE HYDROLASE 1, 7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptane-1,1-diol, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	endoplasmic reticulum, monotopic membrane protein, membrane, hydrolase, transmembrane, phosphoprotein, covalent reversible inhibitors, fatty acid amide hydrolase, golgi apparatus, alpha-ketooxazole
Biological source	RATTUS NORVEGICUS (RAT)
Cellular location	Endoplasmic reticulum membrane; Single-pass membrane protein: P97612
Total number of polymer chains	2
Total formula weight	126963.63
Authors	Mileni, M.,Garfunkle, J.,DeMartino, J.K.,Cravatt, B.F.,Boger, D.L.,Stevens, R.C. (deposition date: 2009-05-19, release date: 2009-09-15, Last modification date: 2023-12-13)
Primary citation	Mileni, M.,Garfunkle, J.,Demartino, J.K.,Cravatt, B.F.,Boger, D.L.,Stevens, R.C. Binding and Inactivation Mechanism of a Humanized Fatty Acid Amide Hydrolase by Alpha-Ketoheterocycle Inhibitors Revealed from Cocrystal Structures. J.Am.Chem.Soc., 131:10497-, 2009 Cited by PubMed: 19722626 DOI: 10.1021/JA902694N PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation