2WJ1

3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with 7-phenyl-1-(4-(pyridin-2-yl)oxazol-2-yl)heptan- 1-one, an alpha-ketooxazole

Summary for 2WJ1

Entry DOI	10.2210/pdb2wj1/pdb
Related	1MT5 2VYA 2WAP
Descriptor	FATTY-ACID AMIDE HYDROLASE 1, 7-phenyl-1-(4-pyridin-2-yl-1,3-oxazol-2-yl)heptane-1,1-diol, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	monotopic membrane protein, fatty acid amide hydrolase, golgi apparatus, endoplasmic reticulum, membrane, hydrolase, transmembrane, phosphoprotein, covalent reversible inhibitor
Biological source	RATTUS NORVEGICUS (RAT)
Cellular location	Endoplasmic reticulum membrane; Single-pass membrane protein: P97612
Total number of polymer chains	2
Total formula weight	126963.63
Authors	Mileni, M.,Garfunkle, J.,DeMartino, J.K.,Cravatt, B.F.,Boger, D.L.,Stevens, R.C. (deposition date: 2009-05-19, release date: 2009-09-15, Last modification date: 2023-12-13)
Primary citation	Mileni, M.,Garfunkle, J.,Demartino, J.K.,Cravatt, B.F.,Boger, D.L.,Stevens, R.C. Binding and Inactivation Mechanism of a Humanized Fatty Acid Amide Hydrolase by Alpha-Ketoheterocycle Inhibitors Revealed from Cocrystal Structures. J.Am.Chem.Soc., 131:10497-, 2009 Cited by PubMed: 19722626 DOI: 10.1021/JA902694N PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.84 Å)

Structure validation