2WJ1
3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with 7-phenyl-1-(4-(pyridin-2-yl)oxazol-2-yl)heptan- 1-one, an alpha-ketooxazole
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | FATTY-ACID AMIDE HYDROLASE 1 | polymer | 573 | 63111.7 | 2 | UniProt (P97612) Pfam (PF01425) In PDB | RATTUS NORVEGICUS (RAT) | OLEAMIDE HYDROLASE 1, ANANDAMIDE AMIDOHYDROLASE 1, FATTY ACID AMIDE HYDROLASE |
2 | A, B | 7-phenyl-1-(4-pyridin-2-yl-1,3-oxazol-2-yl)heptane-1,1-diol | non-polymer | 352.4 | 2 | Chemie (S99) | |||
3 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
4 | water | water | 18.0 | 625 | Chemie (HOH) |
Sequence modifications
A, B: 7 - 29 (PDB: 2WJ1)
A, B: 30 - 579 (UniProt: P97612)
A, B: 30 - 579 (UniProt: P97612)
PDB | External Database | Details |
---|---|---|
Phe 192 | Leu 192 | engineered mutation |
Tyr 194 | Phe 194 | engineered mutation |
Thr 377 | Ala 377 | engineered mutation |
Asn 435 | Ser 435 | engineered mutation |
Val 491 | Ile 491 | engineered mutation |
Met 495 | Val 495 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 126223.3 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 740.3 | |
All* | Total formula weight | 126963.6 |