2VYA

Crystal Structure of fatty acid amide hydrolase conjugated with the drug-like inhibitor PF-750

Summary for 2VYA

Related1MT5
DescriptorFATTY-ACID AMIDE HYDROLASE 1, UNKNOWN ATOM OR ION, 4-(quinolin-3-ylmethyl)piperidine-1-carboxylic acid, ... (5 entities in total)
Functional Keywordshydrolase, fatty acid amide hydrolyse, golgi apparatus, endoplasmic reticulum, inhibitor, drug- like, transmembrane, faah, chimera, membrane, covalent, humanized
Biological sourceRATTUS NORVEGICUS (RAT)
Cellular locationEndoplasmic reticulum membrane; Single-pass membrane protein P97612
Total number of polymer chains2
Total molecular weight130016.57
Authors
Mileni, M.,Johnson, D.S.,Wang, Z.,Everdeen, D.S.,Liimatta, M.,Pabst, B.,Bhattacharya, K.,Nugent, R.A.,Kamtekar, S.,Cravatt, B.F.,Ahn, K.,Stevens, R.C. (deposition date: 2008-07-22, release date: 2008-09-09, Last modification date: 2011-07-13)
Primary citation
Mileni, M.,Johnson, D.S.,Wang, Z.,Everdeen, D.S.,Liimatta, M.,Pabst, B.,Bhattacharya, K.,Nugent, R.A.,Kamtekar, S.,Cravatt, B.F.,Ahn, K.,Stevens, R.C.
Structure-Guided Inhibitor Design for Human Faah by Interspecies Active Site Conversion.
Proc.Natl.Acad.Sci.USA, 105:12820-, 2008
PubMed: 18753625 (PDB entries with the same primary citation)
DOI: 10.1073/PNAS.0806121105
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.75 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.262709.7%2.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution