2VYA
Crystal Structure of fatty acid amide hydrolase conjugated with the drug-like inhibitor PF-750
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | FATTY-ACID AMIDE HYDROLASE 1 | polymer | 587 | 64720.2 | 2 | UniProt (P97612) Pfam (PF01425) In PDB | RATTUS NORVEGICUS (RAT) | FATTY ACID AMIDE HYDROLASE, OLEAMIDE HYDROLASE 1, ANANDAMIDE AMIDOHYDROLASE 1 |
| 2 | A, B | UNKNOWN ATOM OR ION | non-polymer | 4 | Chemie (UNX) | ||||
| 3 | A, B | 4-(quinolin-3-ylmethyl)piperidine-1-carboxylic acid | non-polymer | 270.3 | 2 | Chemie (PF7) | |||
| 4 | B | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | water | water | 18.0 | 84 | Chemie (HOH) |
Sequence modifications
A, B: -7 - 31 (PDB: 2VYA)
A, B: 32 - 579 (UniProt: P97612)
A, B: 32 - 579 (UniProt: P97612)
| PDB | External Database | Details |
|---|---|---|
| Phe 192 | Leu 192 | engineered mutation |
| Tyr 194 | Phe 194 | engineered mutation |
| Thr 377 | Ala 377 | engineered mutation |
| Asn 435 | Ser 435 | engineered mutation |
| Val 491 | Ile 491 | engineered mutation |
| Met 495 | Val 495 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 129440.5 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 576.1 | |
| All* | Total formula weight | 130016.6 |
