2WAP
3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with the drug-like urea inhibitor PF-3845
Summary for 2WAP
Entry DOI | 10.2210/pdb2wap/pdb |
Related | 1MT5 2VYA |
Descriptor | FATTY-ACID AMIDE HYDROLASE 1, 4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzyl)piperidine-1-carboxylic acid, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | fatty acid amide hydrolase, urea inhibitor, golgi apparatus, endoplasmic reticulum, acyl- enzyme, transmembrane, phosphoprotein, faah, drug, membrane, hydrolase, inhibitor |
Biological source | RATTUS NORVEGICUS (RAT) |
Cellular location | Endoplasmic reticulum membrane; Single-pass membrane protein: P97612 |
Total number of polymer chains | 2 |
Total formula weight | 120519.18 |
Authors | Mileni, M.,Kamtekar, S.,Stevens, R.C. (deposition date: 2009-02-11, release date: 2009-05-05, Last modification date: 2023-12-13) |
Primary citation | Ahn, K.,Johnson, D.S.,Mileni, M.,Beidler, D.,Long, J.Z.,Mckinney, M.K.,Weerapana, E.,Sadagopan, N.,Liimatta, M.,Smith, S.E.,Lazerwith, S.,Stiff, C.,Kamtekar, S.,Bhattacharya, K.,Zhang, Y.,Swaney, S.,Vanbecelaere, K.,Stevens, R.C.,Cravatt, B.F. Discovery and Characterization of a Highly Selective Faah Inhibitor that Reduces Inflammatory Pain. Chem.Biol., 16:411-, 2009 Cited by PubMed: 19389627DOI: 10.1016/J.CHEMBIOL.2009.02.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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