2WAP
3D-crystal structure of humanized-rat fatty acid amide hydrolase (FAAH) conjugated with the drug-like urea inhibitor PF-3845
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | FATTY-ACID AMIDE HYDROLASE 1 | polymer | 543 | 59827.0 | 2 | UniProt (P97612) Pfam (PF01425) | RATTUS NORVEGICUS (RAT) | FATTY ACID AMIDE HYDROLASE, OLEAMIDE HYDROLASE 1, ANANDAMIDE AMIDOHYDROLASE 1 |
| 2 | C, F (A, B) | 4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzyl)piperidine-1-carboxylic acid | non-polymer | 380.4 | 2 | Chemie (PIX) | |||
| 3 | D (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | E, G, H (A, B) | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 43 | Chemie (HOH) |
Sequence modifications
A, B: 31 - 573 (UniProt: P97612)
| PDB | External Database | Details |
|---|---|---|
| Phe 192 | Leu 192 | engineered mutation |
| Tyr 194 | Phe 194 | engineered mutation |
| Thr 377 | Ala 377 | engineered mutation |
| Asn 435 | Ser 435 | engineered mutation |
| Val 491 | Ile 491 | engineered mutation |
| Met 495 | Val 495 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 119654.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 865.1 | |
| All* | Total formula weight | 120519.2 |
