3K84

Crystal Structure Analysis of a Oleyl/Oxadiazole/pyridine Inhibitor Bound to a Humanized Variant of Fatty Acid Amide Hydrolase

Summary for 3K84

Entry DOI	10.2210/pdb3k84/pdb
Related	2wj1 2wj2 3k7f 3k83
Descriptor	Fatty-acid amide hydrolase 1, (9Z)-1-(5-pyridin-2-yl-1,3,4-oxadiazol-2-yl)octadec-9-en-1-one, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	faah, oxazole, conjugate, covalent modification, hydrolase, membrane, transmembrane, oxadiazole, alpha-ketoheterocycle, monotopic, fatty acid, serine hydrolase, endocannabinoid, reversible inhibitor.
Biological source	Rattus norvegicus (rat)
Cellular location	Endoplasmic reticulum membrane; Single-pass membrane protein: P97612
Total number of polymer chains	2
Total formula weight	127081.94
Authors	Mileni, M.,Stevens, R.C.,Boger, D.L. (deposition date: 2009-10-13, release date: 2009-12-01, Last modification date: 2023-09-06)
Primary citation	Mileni, M.,Garfunkle, J.,Ezzili, C.,Kimball, F.S.,Cravatt, B.F.,Stevens, R.C.,Boger, D.L. X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase. J.Med.Chem., 53:230-240, 2010 Cited by PubMed: 19924997 DOI: 10.1021/jm9012196 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation