3K7F

Crystal Structure Analysis of a Phenhexyl/Oxazole/Carboxypyridine alpha-Ketoheterocycle Inhibitor Bound to a Humanized Variant of Fatty Acid Amide Hydrolase'

Summary for 3K7F

• Entry DOI: 10.2210/pdb3k7f/pdb
• Related: 2wj1 2wj2
• Descriptor: Fatty-acid amide hydrolase 1, 6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: protein-inhibitor complex, faah, oxazole, hydrolase, membrane, transmembrane
• Biological source: Rattus norvegicus (rat)
• Cellular location: Endoplasmic reticulum membrane; Single-pass membrane protein: P97612
• Total number of polymer chains: 2
• Total formula weight: 127038.61

Authors

Mileni, M.,Stevens, R.C.,Boger, D.L. (deposition date: 2009-10-13, release date: 2009-12-01, Last modification date: 2023-09-06)

• Primary citation: Mileni, M.,Garfunkle, J.,Ezzili, C.,Kimball, F.S.,Cravatt, B.F.,Stevens, R.C.,Boger, D.L.; X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase.; J.Med.Chem., 53:230-240, 2010; PubMed: 19924997; DOI: 10.1021/jm9012196

Experimental method

X-RAY DIFFRACTION (1.95 Å)