3K83

Crystal Structure Analysis of a Biphenyl/Oxazole/Carboxypyridine alpha-ketoheterocycle Inhibitor Bound to a Humanized Variant of Fatty Acid Amide Hydrolase

Summary for 3K83

Entry DOI	10.2210/pdb3k83/pdb
Related	2wj1 2wj2 3K84 3k7f
Descriptor	Fatty-acid amide hydrolase 1, 6-[2-(3-biphenyl-4-ylpropanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	faah, oxazole, conjugate, covalent modification, hydrolase, membrane, transmembrane, monotopic, fatty acid, serine hydrolase, endocannabinoid, reversible inhibitor.
Biological source	Rattus norvegicus (rat)
Cellular location	Endoplasmic reticulum membrane; Single-pass membrane protein: P97612
Total number of polymer chains	2
Total formula weight	127241.94
Authors	Mileni, M.,Stevens, R.C.,Boger, D.L. (deposition date: 2009-10-13, release date: 2009-12-01, Last modification date: 2023-09-06)
Primary citation	Mileni, M.,Garfunkle, J.,Ezzili, C.,Kimball, F.S.,Cravatt, B.F.,Stevens, R.C.,Boger, D.L. X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase. J.Med.Chem., 53:230-240, 2010 Cited by PubMed: 19924997 DOI: 10.1021/jm9012196 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.251 Å)

Structure validation