3PR0
Crystal Structure of a Covalently Bound alpha-Ketoheterocycle Inhibitor (Phenhexyl/Oxadiazole/Pyridine) to a Humanized Variant of Fatty Acid Amide Hydrolase
Summary for 3PR0
Entry DOI | 10.2210/pdb3pr0/pdb |
Related | 2wj1 2wj2 3K7F 3K83 3K84 3ppm |
Descriptor | Fatty Acid Amide Hydrolase 1, 7-phenyl-1-[5-(pyridin-2-yl)-1,3,4-oxadiazol-2-yl]heptane-1,1-diol, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | protein-inhibitor complex, faah, oxadiazole, alpha-ketoheterocycle, endocannabinoid degradation, membrane protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Rattus norvegicus (rat) |
Cellular location | Endoplasmic reticulum membrane; Single-pass membrane protein: P97612 |
Total number of polymer chains | 2 |
Total formula weight | 127177.85 |
Authors | Mileni, M.,Han, G.W.,Boger, D.L.,Stevens, R.C. (deposition date: 2010-11-29, release date: 2011-11-16, Last modification date: 2023-09-06) |
Primary citation | Mileni, M.,Garfunkle, J.,Ezzili, C.,Cravatt, B.F.,Stevens, R.C.,Boger, D.L. Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent alpha-ketoheterocycle inhibitor of fatty acid amide hydrolase. J.Am.Chem.Soc., 133:4092-4100, 2011 Cited by PubMed: 21355555DOI: 10.1021/ja110877y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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