7SP1
| RNA-induced tau amyloid fibril | 分子名称: | Isoform Tau-F of Microtubule-associated protein tau, RNA (5'-R(*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') | 著者 | Abskharon, R, Sawaya, M.R, Boyer, D.R, Eisenberg, D.S. | 登録日 | 2021-11-02 | 公開日 | 2022-03-30 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation. Proc.Natl.Acad.Sci.USA, 119, 2022
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6PK8
| Antibody scFv-M204 dimeric state | 分子名称: | SULFATE ION, scFv-M204 antibody | 著者 | Abskharon, R, Sawaya, M.R, Seidler, P.M, Cascio, D, Eisenberg, D.S. | 登録日 | 2019-06-28 | 公開日 | 2020-06-24 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | 主引用文献 | Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease. J.Biol.Chem., 295, 2020
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6PSC
| Antibody scFv-M204 trimeric state | 分子名称: | scFv-M204 antibody | 著者 | Abskharon, R, Sawaya, M.R, Seidler, P.M, Cascio, D, Eisenberg, D.S. | 登録日 | 2019-07-12 | 公開日 | 2020-06-17 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease. J.Biol.Chem., 295, 2020
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6PIL
| Antibody scFv-M204 monomeric state | 分子名称: | CHLORIDE ION, scFv-M204 antibody | 著者 | Abskharon, R, Sawaya, M.R, Seidler, P.M, Cascio, D, Eisenberg, D.S. | 登録日 | 2019-06-26 | 公開日 | 2020-06-24 | 最終更新日 | 2020-08-12 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease. J.Biol.Chem., 295, 2020
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8FQ7
| Nanobody with WIW inserted in CDR3 loop to Inhibit Growth of Alzheimer's Tau fibrils | 分子名称: | GLYCEROL, Nanobody with WIW insert in CDR3 loop to target tau fibrils | 著者 | Abskharon, R, Sawaya, M.R, Cascio, D.C, Eisenberg, D.S. | 登録日 | 2023-01-05 | 公開日 | 2023-10-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils. Proc.Natl.Acad.Sci.USA, 120, 2023
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6HER
| Mouse prion protein in complex with Nanobody 484 | 分子名称: | GLYCEROL, Major prion protein, Nanobody 484, ... | 著者 | Soror, S.H, Abskharon, R, Wohlkonig, A. | 登録日 | 2018-08-20 | 公開日 | 2019-12-04 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.199 Å) | 主引用文献 | Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion. Plos Pathog., 15, 2019
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6HHD
| Mouse Prion Protein in complex with Nanobody 484 | 分子名称: | CHLORIDE ION, GLYCEROL, Major prion protein, ... | 著者 | Soror, S, Abskharon, R, Wohlkonig, A. | 登録日 | 2018-08-28 | 公開日 | 2019-12-11 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.102 Å) | 主引用文献 | Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion. Plos Pathog., 15, 2019
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8TER
| Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG) Low Complexity Domain (residues 237-327) P285L mutant, amyloid fiber | 分子名称: | TRK-fused gene protein Low Complexity Domain P285L mutant | 著者 | Rosenberg, G.M, Sawaya, M.R, Boyer, D.R, Ge, P, Abskharon, R, Eisenberg, D.S. | 登録日 | 2023-07-06 | 公開日 | 2023-12-20 | 最終更新日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (2.59 Å) | 主引用文献 | Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method. Pnas Nexus, 2, 2023
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8TEQ
| Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG) Low Complexity Domain (residues 237-327) G269V mutant, amyloid fiber | 分子名称: | TRK-fused gene protein Low Complexity Domain G269V mutant | 著者 | Rosenberg, G.M, Sawaya, M.R, Boyer, D.R, Ge, P, Abskharon, R, Eisenberg, D.S. | 登録日 | 2023-07-06 | 公開日 | 2023-12-20 | 最終更新日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | 主引用文献 | Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method. Pnas Nexus, 2, 2023
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6HEQ
| Prion nanobody 484 | 分子名称: | Prion nanobody 484 | 著者 | Soror, S.H, Abskharon, R.N, Wohlkonig, A. | 登録日 | 2018-08-20 | 公開日 | 2019-12-04 | 最終更新日 | 2019-12-18 | 実験手法 | X-RAY DIFFRACTION (1.23 Å) | 主引用文献 | Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion. Plos Pathog., 15, 2019
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7UPE
| Tau Paired Helical Filament from Alzheimer's Disease not incubated with EGCG | 分子名称: | Isoform Tau-F of Microtubule-associated protein tau | 著者 | Seidler, P.M, Murray, K.A, Boyer, D.R, Ge, P, Sawaya, M.R, Eisenberg, D.S. | 登録日 | 2022-04-15 | 公開日 | 2022-09-28 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro. Nat Commun, 13, 2022
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7UPF
| Tau Paired Helical Filament from Alzheimer's Disease incubated 1 hr. with EGCG | 分子名称: | Isoform Tau-F of Microtubule-associated protein tau | 著者 | Seidler, P.M, Murray, K.A, Boyer, D.R, Ge, P, Sawaya, M.R, Eisenberg, D.S. | 登録日 | 2022-04-15 | 公開日 | 2022-09-28 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro. Nat Commun, 13, 2022
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7UPG
| Tau Paired Helical Filament from Alzheimer's Disease incubated with EGCG for 3 hours | 分子名称: | (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, Isoform Tau-F of Microtubule-associated protein tau | 著者 | Seidler, P.M, Murray, K.A, Boyer, D.R, Ge, P, Sawaya, M.R, Eisenberg, D.S. | 登録日 | 2022-04-15 | 公開日 | 2022-09-28 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro. Nat Commun, 13, 2022
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8DU2
| HnRNPA2 D290V LCD PM1 | 分子名称: | Heterogeneous nuclear ribonucleoproteins A2/B1 | 著者 | Eisenberg, D.S, Lu, J, Ge, P, Boyer, D.R. | 登録日 | 2022-07-26 | 公開日 | 2023-08-02 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation. J.Biol.Chem., 300, 2023
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8DUW
| HnRNPA2 D290V LCD PM2 | 分子名称: | Heterogeneous nuclear ribonucleoproteins A2/B1 | 著者 | Eisenberg, D.S, Lu, J, Ge, P, Boyer, D.R. | 登録日 | 2022-07-27 | 公開日 | 2023-08-02 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation. J.Biol.Chem., 300, 2023
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8EC7
| HnRNPA2 D290V LCD PM3 | 分子名称: | Heterogeneous nuclear ribonucleoproteins A2/B1 | 著者 | Eisenberg, D.S, Lu, J, Ge, P, Boyer, D.R. | 登録日 | 2022-09-01 | 公開日 | 2023-09-06 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation. J.Biol.Chem., 300, 2023
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7SAS
| Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 3 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B | 著者 | Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S. | 登録日 | 2021-09-23 | 公開日 | 2022-03-09 | 最終更新日 | 2022-05-25 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43. Nature, 605, 2022
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7SAQ
| Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B | 著者 | Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S. | 登録日 | 2021-09-23 | 公開日 | 2022-03-09 | 最終更新日 | 2022-05-25 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43. Nature, 605, 2022
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7SAR
| Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B | 著者 | Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S. | 登録日 | 2021-09-23 | 公開日 | 2022-03-09 | 最終更新日 | 2022-05-25 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43. Nature, 605, 2022
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7LUX
| AALALL segment from the Nucleoprotein of SARS-CoV-2, residues 217-222, crystal form 2 | 分子名称: | Nucleoprotein AALALL, TETRAETHYLENE GLYCOL | 著者 | Lu, J, Zee, C.-T, Sawaya, M.R, Rodriguez, J.A, Eisenberg, D.S. | 登録日 | 2021-02-23 | 公開日 | 2021-03-17 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.303 Å) | 主引用文献 | Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2. Biorxiv, 2021
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7LUZ
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7LV2
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7LTU
| AALALL SEGMENT FROM THE NUCLEOPROTEIN OF SARS-COV-2, RESIDUES 217-222, CRYSTAL FORM 1 | 分子名称: | AALALL SEGMENT FROM THE NUCLEOPROTEIN OF SARS-COV-2,RESIDUES 217-222, trifluoroacetic acid | 著者 | Zee, C.-T, Sawaya, M.R, Rodriguez, J.A, Eisenberg, D.S. | 登録日 | 2021-02-20 | 公開日 | 2021-03-17 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.122 Å) | 主引用文献 | Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2. Biorxiv, 2021
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7M62
| Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 2 | 分子名称: | Islet amyloid polypeptide | 著者 | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | 登録日 | 2021-03-25 | 公開日 | 2021-09-22 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores Nat.Struct.Mol.Biol., 28, 2021
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7M65
| Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 4 | 分子名称: | Islet amyloid polypeptide | 著者 | Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S. | 登録日 | 2021-03-25 | 公開日 | 2021-09-22 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores Nat.Struct.Mol.Biol., 28, 2021
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