8TER

Tropomyosin-receptor kinase fused gene protein (TRK-fused gene protein; TFG) Low Complexity Domain (residues 237-327) P285L mutant, amyloid fiber

Summary for 8TER

Entry DOI	10.2210/pdb8ter/pdb
Related	8TEQ
EMDB information	41198
Descriptor	TRK-fused gene protein Low Complexity Domain P285L mutant (2 entities in total)
Functional Keywords	amyloid, mutation, charcot-marie-tooth disease, hereditary motor and sensory neuropathy with proximal dominant involvement, protein fibril
Biological source	Purpureocillium lilacinum More
Total number of polymer chains	20
Total formula weight	809295.08
Authors	Rosenberg, G.M.,Sawaya, M.R.,Boyer, D.R.,Ge, P.,Abskharon, R.,Eisenberg, D.S. (deposition date: 2023-07-06, release date: 2023-12-20, Last modification date: 2023-12-27)
Primary citation	Rosenberg, G.M.,Abskharon, R.,Boyer, D.R.,Ge, P.,Sawaya, M.R.,Eisenberg, D.S. Fibril structures of TFG protein mutants validate the identification of TFG as a disease-related amyloid protein by the IMPAcT method. Pnas Nexus, 2:pgad402-pgad402, 2023 Cited by PubMed: 38077690 DOI: 10.1093/pnasnexus/pgad402 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.59 Å)

Structure validation