8FQ7
Nanobody with WIW inserted in CDR3 loop to Inhibit Growth of Alzheimer's Tau fibrils
Summary for 8FQ7
| Entry DOI | 10.2210/pdb8fq7/pdb |
| Descriptor | Nanobody with WIW insert in CDR3 loop to target tau fibrils, GLYCEROL (3 entities in total) |
| Functional Keywords | anti-tau antibody, nanobody, immune system |
| Biological source | Camelus dromedarius |
| Total number of polymer chains | 1 |
| Total formula weight | 13860.28 |
| Authors | Abskharon, R.,Sawaya, M.R.,Cascio, D.C.,Eisenberg, D.S. (deposition date: 2023-01-05, release date: 2023-10-04, Last modification date: 2023-10-18) |
| Primary citation | Abskharon, R.,Pan, H.,Sawaya, M.R.,Seidler, P.M.,Olivares, E.J.,Chen, Y.,Murray, K.A.,Zhang, J.,Lantz, C.,Bentzel, M.,Boyer, D.R.,Cascio, D.,Nguyen, B.A.,Hou, K.,Cheng, X.,Pardon, E.,Williams, C.K.,Nana, A.L.,Vinters, H.V.,Spina, S.,Grinberg, L.T.,Seeley, W.W.,Steyaert, J.,Glabe, C.G.,Ogorzalek Loo, R.R.,Loo, J.A.,Eisenberg, D.S. Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils. Proc.Natl.Acad.Sci.USA, 120:e2300258120-e2300258120, 2023 Cited by PubMed: 37801475DOI: 10.1073/pnas.2300258120 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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