6HHD

Mouse Prion Protein in complex with Nanobody 484

Summary for 6HHD

Entry DOI	10.2210/pdb6hhd/pdb
Descriptor	Major prion protein, Nanobody 484, CHLORIDE ION, ... (9 entities in total)
Functional Keywords	prion, nanobody, aggregation, b-sheet, protein binding
Biological source	Mus musculus (House Mouse) More
Total number of polymer chains	4
Total formula weight	53055.00
Authors	Soror, S.,Abskharon, R.,Wohlkonig, A. (deposition date: 2018-08-28, release date: 2019-12-11, Last modification date: 2024-01-17)
Primary citation	Abskharon, R.,Wang, F.,Wohlkonig, A.,Ruan, J.,Soror, S.,Giachin, G.,Pardon, E.,Zou, W.,Legname, G.,Ma, J.,Steyaert, J. Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion. Plos Pathog., 15:e1008139-e1008139, 2019 Cited by PubMed: 31815959 DOI: 10.1371/journal.ppat.1008139 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.102 Å)

Structure validation