7M65

Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 4

Summary for 7M65

Entry DOI	10.2210/pdb7m65/pdb
EMDB information	23686 23687 23688 23689
Descriptor	Islet amyloid polypeptide (1 entity in total)
Functional Keywords	hiapp, type ii diabetes, amyloid, protein fibril
Biological source	Homo sapiens (Human)
Total number of polymer chains	10
Total formula weight	39073.12
Authors	Cao, Q.,Boyer, D.R.,Sawaya, M.R.,Eisenberg, D.S. (deposition date: 2021-03-25, release date: 2021-09-22, Last modification date: 2024-11-20)
Primary citation	Cao, Q.,Boyer, D.R.,Sawaya, M.R.,Abskharon, R.,Saelices, L.,Nguyen, B.A.,Lu, J.,Murray, K.A.,Kandeel, F.,Eisenberg, D.S. Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores Nat.Struct.Mol.Biol., 28:724-730, 2021 Cited by DOI: 10.1038/s41594-021-00646-x PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.1 Å)

Structure validation