7M65

Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005179	molecular_function	hormone activity
A	0005576	cellular_component	extracellular region
B	0005179	molecular_function	hormone activity
B	0005576	cellular_component	extracellular region
C	0005179	molecular_function	hormone activity
C	0005576	cellular_component	extracellular region
D	0005179	molecular_function	hormone activity
D	0005576	cellular_component	extracellular region
E	0005179	molecular_function	hormone activity
E	0005576	cellular_component	extracellular region
F	0005179	molecular_function	hormone activity
F	0005576	cellular_component	extracellular region
G	0005179	molecular_function	hormone activity
G	0005576	cellular_component	extracellular region
H	0005179	molecular_function	hormone activity
H	0005576	cellular_component	extracellular region
I	0005179	molecular_function	hormone activity
I	0005576	cellular_component	extracellular region
J	0005179	molecular_function	hormone activity
J	0005576	cellular_component	extracellular region

Functional Information from PROSITE/UniProt

site_id	PS00258
Number of Residues	15
Details	CALCITONIN Calcitonin / CGRP / IAPP family signature. CNT.ATCAtqrLanfL

Chain	Residue	Details
A	CYS2-LEU16

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	MOD_RES: Tyrosine amide => ECO:0000269|PubMed:2651160, ECO:0000269|PubMed:3053705

Chain	Residue	Details
A	TYR37
J	TYR37
B	TYR37
C	TYR37
D	TYR37
E	TYR37
F	TYR37
G	TYR37
H	TYR37
I	TYR37

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