6PK8

Antibody scFv-M204 dimeric state

Summary for 6PK8

Entry DOI	10.2210/pdb6pk8/pdb
Descriptor	scFv-M204 antibody, SULFATE ION (3 entities in total)
Functional Keywords	anti-tau-oligomer scfv antibody, immune system
Biological source	Oryctolagus cuniculus
Total number of polymer chains	4
Total formula weight	108632.08
Authors	Abskharon, R.,Sawaya, M.R.,Seidler, P.M.,Cascio, D.,Eisenberg, D.S. (deposition date: 2019-06-28, release date: 2020-06-24, Last modification date: 2023-10-11)
Primary citation	Abskharon, R.,Seidler, P.M.,Sawaya, M.R.,Cascio, D.,Yang, T.P.,Philipp, S.,Williams, C.K.,Newell, K.L.,Ghetti, B.,DeTure, M.A.,Dickson, D.W.,Vinters, H.V.,Felgner, P.L.,Nakajima, R.,Glabe, C.G.,Eisenberg, D.S. Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease. J.Biol.Chem., 295:10662-10676, 2020 Cited by PubMed: 32493775 DOI: 10.1074/jbc.RA120.013638 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.91 Å)

Structure validation