7SAS

Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 3

Summary for 7SAS

Entry DOI	10.2210/pdb7sas/pdb
EMDB information	24955
Descriptor	Transmembrane protein 106B, 2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total)
Functional Keywords	tmem106b, ftld-tdp, amyloid, protein fibril
Biological source	Homo sapiens (Human)
Total number of polymer chains	10
Total formula weight	320411.50
Authors	Cao, Q.,Jiang, Y.,Sawaya, M.R.,Eisenberg, D.S. (deposition date: 2021-09-23, release date: 2022-03-09, Last modification date: 2022-05-25)
Primary citation	Jiang, Y.X.,Cao, Q.,Sawaya, M.R.,Abskharon, R.,Ge, P.,DeTure, M.,Dickson, D.W.,Fu, J.Y.,Ogorzalek Loo, R.R.,Loo, J.A.,Eisenberg, D.S. Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43. Nature, 605:304-309, 2022 Cited by PubMed: 35344984 DOI: 10.1038/s41586-022-04670-9 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.7 Å)

Structure validation