4LAF
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4LA4
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6D27
| Crystal structure of the prostaglandin D2 receptor CRTH2 with CAY10471 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, OLEIC ACID, ... | 著者 | Wang, L, Yao, D, Deepak, K, Liu, H, Gong, W, Fan, H, Wei, Z, Zhang, C. | 登録日 | 2018-04-13 | 公開日 | 2018-10-03 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.738 Å) | 主引用文献 | Structures of the Human PGD2Receptor CRTH2 Reveal Novel Mechanisms for Ligand Recognition. Mol. Cell, 72, 2018
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7XD7
| The pre-Tet-C state of wild-type Tetrahymena group I intron with 30nt 3'/5'-exon | 分子名称: | MAGNESIUM ION, SPERMIDINE, The pre-Tet-C state molecule of co-transcriptional folded wild-type Tetrahymena group I intron with 30nt 3'/5'-exon | 著者 | Luo, B, Zhang, C, Ling, X, Mukherjee, S, Jia, G, Xie, J, Jia, X, Liu, L, Baulin, E.F, Luo, Y, Jiang, L, Dong, H, Wei, X, Bujnicki, J.M, Su, Z. | 登録日 | 2022-03-26 | 公開日 | 2023-03-29 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | 主引用文献 | Cryo-EM reveals dynamics of Tetrahymena group I intron self-splicing Nat Catal, 2023
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7XD3
| The relaxed pre-Tet-S1 state of wild-type Tetrahymena group I intron with 6nt 3'/5'-exon | 分子名称: | MAGNESIUM ION, The relaxed pre-Tet-S1 state molecule of co-transcriptional folded wild-type Tetrahymena group I intron with 6nt 3'/5'-exon | 著者 | Luo, B, Zhang, C, Ling, X, Mukherjee, S, Jia, G, Xie, J, Jia, X, Liu, L, Baulin, E.F, Luo, Y, Jiang, L, Dong, H, Wei, X, Bujnicki, J.M, Su, Z. | 登録日 | 2022-03-26 | 公開日 | 2023-03-29 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (4.05 Å) | 主引用文献 | Cryo-EM reveals dynamics of Tetrahymena group I intron self-splicing Nat Catal, 2023
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7XD4
| The intermediate pre-Tet-S1 state of wild-type Tetrahymena group I intron with 6nt 3'/5'-exon | 分子名称: | Co-transcriptional folded wild-type Tetrahymena group I intron with 6nt 3'/5'-exon, MAGNESIUM ION | 著者 | Luo, B, Zhang, C, Ling, X, Mukherjee, S, Jia, G, Xie, J, Jia, X, Liu, L, Baulin, E.F, Luo, Y, Jiang, L, Dong, H, Wei, X, Bujnicki, J.M, Su, Z. | 登録日 | 2022-03-26 | 公開日 | 2023-03-29 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.89 Å) | 主引用文献 | Cryo-EM reveals dynamics of Tetrahymena group I intron self-splicing Nat Catal, 2023
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7XD5
| The Tet-S2 state of wild-type Tetrahymena group I intron with 30nt 3'/5'-exon | 分子名称: | MAGNESIUM ION, SPERMIDINE, The Tet-S2 state molecule of co-transcriptional folded wild-type Tetrahymena group I intron with 30nt 3'/5'-exon (5'-exon), ... | 著者 | Luo, B, Zhang, C, Ling, X, Mukherjee, S, Jia, G, Xie, J, Jia, X, Liu, L, Baulin, E.F, Luo, Y, Jiang, L, Dong, H, Wei, X, Bujnicki, J.M, Su, Z. | 登録日 | 2022-03-26 | 公開日 | 2023-04-05 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | 主引用文献 | Cryo-EM reveals dynamics of Tetrahymena group I intron self-splicing Nat Catal, 2023
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7XD6
| The Tet-S2 state with a pseudoknotted 4-way junction of wild-type Tetrahymena group I intron with 30nt 3'/5'-exon | 分子名称: | MAGNESIUM ION, SPERMIDINE, The Tet-S2 state with a pseudoknotted 4-way junction molecule of co-transcriptional folded wild-type Tetrahymena group I intron with 30nt 3'/5'-exon (5'-exon), ... | 著者 | Luo, B, Zhang, C, Ling, X, Mukherjee, S, Jia, G, Xie, J, Jia, X, Liu, L, Baulin, E.F, Luo, Y, Jiang, L, Dong, H, Wei, X, Bujnicki, J.M, Su, Z. | 登録日 | 2022-03-26 | 公開日 | 2023-04-05 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | 主引用文献 | Cryo-EM reveals dynamics of Tetrahymena group I intron self-splicing Nat Catal, 2023
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3UON
| Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist | 分子名称: | (3R)-1-azabicyclo[2.2.2]oct-3-yl hydroxy(diphenyl)acetate, CHLORIDE ION, Human M2 muscarinic acetylcholine, ... | 著者 | Haga, K, Kruse, A.C, Asada, H, Yurugi-Kobayashi, T, Shiroishi, M, Zhang, C, Weis, W.I, Okada, T, Kobilka, B.K, Haga, T, Kobayashi, T. | 登録日 | 2011-11-16 | 公開日 | 2012-02-01 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist. Nature, 482, 2012
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3TG2
| Crystal structure of the ISC domain of VibB in complex with isochorismate | 分子名称: | (5S,6S)-5-[(1-carboxyethenyl)oxy]-6-hydroxycyclohexa-1,3-diene-1-carboxylic acid, TRIETHYLENE GLYCOL, Vibriobactin-specific isochorismatase | 著者 | Liu, S, Zhang, C, Niu, B, Li, N, Liu, X, Liu, M, Wei, T, Zhu, D, Huang, Y, Xu, S, Gu, L. | 登録日 | 2011-08-17 | 公開日 | 2012-08-29 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.101 Å) | 主引用文献 | Structural insight into the ISC domain of VibB from Vibrio cholerae at atomic resolution: a snapshot just before the enzymatic reaction Acta Crystallogr.,Sect.D, 68, 2012
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8T3V
| Cryo-EM structure of the DHA bound FFA1-Gq complex | 分子名称: | CHOLESTEROL, DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 1, ... | 著者 | Zhang, X, Tikhonova, I, Milligan, G, Zhang, C. | 登録日 | 2023-06-07 | 公開日 | 2024-01-24 | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | 主引用文献 | Structural basis for the ligand recognition and signaling of free fatty acid receptors. Sci Adv, 10, 2024
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8SG1
| Cryo-EM structure of CMKLR1 signaling complex | 分子名称: | CHOLESTEROL, Chemerin 9, Chemerin-like receptor 1, ... | 著者 | Zhang, X, Zhang, C. | 登録日 | 2023-04-11 | 公開日 | 2023-11-01 | 最終更新日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | 主引用文献 | Structural basis of G protein-Coupled receptor CMKLR1 activation and signaling induced by a chemerin-derived agonist. Plos Biol., 21, 2023
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8T3Q
| Cryo-EM structure of the DHA bound FFA4-Gq complex | 分子名称: | DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Zhang, X, Tikhonova, I, Milligan, G, Zhang, C. | 登録日 | 2023-06-07 | 公開日 | 2024-01-24 | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | 主引用文献 | Structural basis for the ligand recognition and signaling of free fatty acid receptors. Sci Adv, 10, 2024
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8T3O
| Cryo-EM structure of the TUG-891 bound FFA4-Gq complex | 分子名称: | (2R)-1-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate, 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, ... | 著者 | Zhang, X, Tikhonova, I, Milligan, G, Zhang, C. | 登録日 | 2023-06-07 | 公開日 | 2024-01-17 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Structural basis for the ligand recognition and signaling of free fatty acid receptors. Sci Adv, 10, 2024
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8T3S
| Cryo-EM structure of the Butyrate bound FFA2-Gq complex | 分子名称: | CHOLESTEROL, Free fatty acid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Zhang, X, Tikhonova, I, Milligan, G, Zhang, C. | 登録日 | 2023-06-07 | 公開日 | 2024-01-24 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | Structural basis for the ligand recognition and signaling of free fatty acid receptors. Sci Adv, 10, 2024
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3R5T
| Crystal structure of holo-ViuP | 分子名称: | (4S,5R)-N-{3-[(2,3-dihydroxybenzoyl)amino]propyl}-2-(2,3-dihydroxyphenyl)-N-[3-({[(4S,5R)-2-(2,3-dihydroxyphenyl)-5-met hyl-4,5-dihydro-1,3-oxazol-4-yl]carbonyl}amino)propyl]-5-methyl-4,5-dihydro-1,3-oxazole-4-carboxamide, 1,2-ETHANEDIOL, ACETIC ACID, ... | 著者 | Li, N, Zhang, C, Li, B, Liu, X, Huang, Y, Xu, S, Gu, L. | 登録日 | 2011-03-19 | 公開日 | 2012-02-08 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Unique iron coordination in iron-chelating molecule vibriobactin helps Vibrio cholerae evade mammalian siderocalin-mediated immune response. J.Biol.Chem., 287, 2012
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3PDS
| Irreversible Agonist-Beta2 Adrenoceptor Complex | 分子名称: | 8-hydroxy-5-[(1R)-1-hydroxy-2-({2-[3-methoxy-4-(3-sulfanylpropoxy)phenyl]ethyl}amino)ethyl]quinolin-2(1H)-one, CHOLESTEROL, Fusion protein Beta-2 adrenergic receptor/Lysozyme, ... | 著者 | Rosenbaum, D.M, Zhang, C, Lyons, J.A, Holl, R, Aragao, D, Arlow, D.H, Rasmussen, S.G.F, Choi, H.-J, DeVree, B.T, Sunahara, R.K, Chae, P.S, Gellman, S.H, Dror, R.O, Shaw, D.E, Weis, W.I, Caffrey, M, Gmeiner, P, Kobilka, B.K. | 登録日 | 2010-10-24 | 公開日 | 2011-01-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Structure and function of an irreversible agonist-beta(2) adrenoceptor complex Nature, 469, 2011
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3Q7J
| Engineered Thermoplasma Acidophilum F3 factor mimics human aminopeptidase N (APN) as a target for anticancer drug development | 分子名称: | L-phenylalanyl-N6-[(benzyloxy)carbonyl]-N1-hydroxy-L-lysinamide, Tricorn protease-interacting factor F3, ZINC ION | 著者 | Su, J, Wang, Q, Feng, J, Zhang, C, Zhu, D, We, T, Xu, W, Gu, L. | 登録日 | 2011-01-05 | 公開日 | 2011-07-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | 主引用文献 | Engineered Thermoplasma acidophilum factor F3 mimics human aminopeptidase N (APN) as a target for anticancer drug development Bioorg.Med.Chem., 19, 2011
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3SDJ
| Structure of RNase-inactive point mutant of oligomeric kinase/RNase Ire1 | 分子名称: | N~2~-1H-benzimidazol-5-yl-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine, Serine/threonine-protein kinase/endoribonuclease IRE1 | 著者 | Korennykh, A, Korostelev, A, Egea, P, Finer-Moore, J, Zhang, C, Stroud, R, Shokat, K, Walter, P. | 登録日 | 2011-06-09 | 公開日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (3.65 Å) | 主引用文献 | Structural and functional basis for RNA cleavage by Ire1. Bmc Biol., 9, 2011
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3R5S
| Crystal structure of apo-ViuP | 分子名称: | Ferric vibriobactin ABC transporter, periplasmic ferric vibriobactin-binding protein | 著者 | Li, N, Zhang, C, Li, B, Liu, X, Huang, Y, Xu, S, Gu, L. | 登録日 | 2011-03-19 | 公開日 | 2012-02-08 | 最終更新日 | 2012-05-30 | 実験手法 | X-RAY DIFFRACTION (1.791 Å) | 主引用文献 | Unique iron coordination in iron-chelating molecule vibriobactin helps Vibrio cholerae evade mammalian siderocalin-mediated immune response. J.Biol.Chem., 287, 2012
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5MJB
| Kinase domain of human EphB1, G703C mutant, covalently bound to a quinazoline-based inhibitor | 分子名称: | 2-chloranyl-~{N}-[4-[(2-chloranyl-5-oxidanyl-phenyl)amino]quinazolin-7-yl]ethanamide, Ephrin type-B receptor 1, SULFATE ION | 著者 | Kung, A, Schimpl, M, Chen, Y.-C, Overman, R.C, Zhang, C. | 登録日 | 2016-11-30 | 公開日 | 2017-05-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | A Chemical-Genetic Approach to Generate Selective Covalent Inhibitors of Protein Kinases. ACS Chem. Biol., 12, 2017
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5MJA
| Kinase domain of human EphB1 bound to a quinazoline-based inhibitor | 分子名称: | 2-chloranyl-~{N}-[4-[(2-chloranyl-5-oxidanyl-phenyl)amino]quinazolin-7-yl]ethanamide, Ephrin type-B receptor 1, SULFATE ION | 著者 | Kung, A, Schimpl, M, Chen, Y.-C, Overman, R.C, Zhang, C. | 登録日 | 2016-11-30 | 公開日 | 2017-05-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | A Chemical-Genetic Approach to Generate Selective Covalent Inhibitors of Protein Kinases. ACS Chem. Biol., 12, 2017
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8ID6
| Cryo-EM structure of the oleic acid bound GPR120-Gi complex | 分子名称: | Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | 登録日 | 2023-02-12 | 公開日 | 2023-03-15 | 最終更新日 | 2023-05-03 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
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8ID9
| Cryo-EM structure of the eicosapentaenoic acid bound GPR120-Gi complex | 分子名称: | 5,8,11,14,17-EICOSAPENTAENOIC ACID, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | 登録日 | 2023-02-12 | 公開日 | 2023-03-15 | 最終更新日 | 2023-05-03 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
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8ID4
| Cryo-EM structure of the linoleic acid bound GPR120-Gi complex | 分子名称: | Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Mao, C, Xiao, P, Tao, X, Qin, J, He, Q, Zhang, C, Yu, X, Zhang, Y, Sun, J. | 登録日 | 2023-02-12 | 公開日 | 2023-03-15 | 最終更新日 | 2023-05-03 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Unsaturated bond recognition leads to biased signal in a fatty acid receptor. Science, 380, 2023
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