5MJA

Kinase domain of human EphB1 bound to a quinazoline-based inhibitor

Summary for 5MJA

Entry DOI	10.2210/pdb5mja/pdb
Descriptor	Ephrin type-B receptor 1, 2-chloranyl-~{N}-[4-[(2-chloranyl-5-oxidanyl-phenyl)amino]quinazolin-7-yl]ethanamide, SULFATE ION, ... (4 entities in total)
Functional Keywords	receptor tyrosine kinase, kinase domain, inhibitor, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane ; Single-pass type I membrane protein : P54762
Total number of polymer chains	2
Total formula weight	70633.75
Authors	Kung, A.,Schimpl, M.,Chen, Y.-C.,Overman, R.C.,Zhang, C. (deposition date: 2016-11-30, release date: 2017-05-17, Last modification date: 2024-01-17)
Primary citation	Kung, A.,Schimpl, M.,Ekanayake, A.,Chen, Y.C.,Overman, R.,Zhang, C. A Chemical-Genetic Approach to Generate Selective Covalent Inhibitors of Protein Kinases. ACS Chem. Biol., 12:1499-1503, 2017 Cited by PubMed: 28459525 DOI: 10.1021/acschembio.6b01083 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.14 Å)

Structure validation