5MJA

Kinase domain of human EphB1 bound to a quinazoline-based inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Ephrin type-B receptor 1	polymer	305	34857.6	2	UniProt (P54762) Pfam (PF07714) In PDB	Homo sapiens (Human)	ELK,EPH tyrosine kinase 2,EPH-like kinase 6,hEK6,Neuronally-expressed EPH-related tyrosine kinase,NET,Tyrosine-protein kinase receptor EPH-2
2	A, B	2-chloranyl-~{N}-[4-[(2-chloranyl-5-oxidanyl-phenyl)amino]quinazolin-7-yl]ethanamide	non-polymer		363.2	2	Chemie (7O3)
3	A, B	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4		water	water		18.0	340	Chemie (HOH)

Sequence modifications

A, B: 602 - 896 (UniProt: P54762)

PDB	External Database	Details
Met 592	-	initiating methionine
Gly 593	-	expression tag
His 594	-	expression tag
His 595	-	expression tag
His 596	-	expression tag
His 597	-	expression tag
His 598	-	expression tag
His 599	-	expression tag
Gly 600	-	expression tag
Ser 601	-	expression tag
Arg 678	Pro 678	conflict
Ser 736	Ala 736	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	69715.2
Non-Polymers*	Number of molecules	4
	Total formula weight	918.5
All*	Total formula weight	70633.7

*Water molecules are not included.