6IIU
| Crystal structure of the human thromboxane A2 receptor bound to ramatroban | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid, CHOLESTEROL, ... | 著者 | Fan, H, Zhao, Q, Wu, B. | 登録日 | 2018-10-07 | 公開日 | 2018-12-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis for ligand recognition of the human thromboxane A2receptor. Nat. Chem. Biol., 15, 2019
|
|
8JRU
| Cryo-EM structure of the glucagon receptor bound to beta-arrestin 1 in ligand-free state | 分子名称: | Beta-arrestin 1 and single-chain fragment variable 30 (scFv30), HA signal peptide,HPC4 purification tag,Glucagon receptor,C-terminal tail of Vasopressin V2 receptor, Nanobody 32, ... | 著者 | Chen, K, Zhang, C, Lin, S, Zhao, Q, Wu, B. | 登録日 | 2023-06-17 | 公開日 | 2023-08-16 | 最終更新日 | 2023-09-13 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Tail engagement of arrestin at the glucagon receptor. Nature, 620, 2023
|
|
8JRV
| Cryo-EM structure of the glucagon receptor bound to glucagon and beta-arrestin 1 | 分子名称: | Beta-arrestin 1 and single-chain fragment variable 30 (scFv30), Glucagon, HA signal peptide,HPC4 purification tag,Glucagon receptor,C-terminal tail of Vasopressin V2 receptor, ... | 著者 | Chen, K, Zhang, C, Lin, S, Zhao, Q, Wu, B. | 登録日 | 2023-06-17 | 公開日 | 2023-08-16 | 最終更新日 | 2023-09-13 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Tail engagement of arrestin at the glucagon receptor. Nature, 620, 2023
|
|
6WKN
| PL-bound rat TRPV2 in nanodiscs | 分子名称: | Transient receptor potential cation channel subfamily V member 2, piperlongumine | 著者 | Pumroy, R.P, Moiseenkova-Bell, V.Y. | 登録日 | 2020-04-16 | 公開日 | 2021-04-21 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | 主引用文献 | Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression. Acs Cent.Sci., 7, 2021
|
|
7MBO
| FACTOR XIA (PICHIA PASTORIS; C500S [C122S]) IN COMPLEX WITH THE INHIBITOR Milvexian (BMS-986177), IUPAC NAME:(6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)phenyl]-6- oxopyrimidin-1(6H)-yl}-1-(difluoromethyl)-6-methyl-1,4,7,8,9,10-hexahydro-15,11- (metheno)pyrazolo[4,3-b][1,7]diazacyclotetradecin-5(6H)-one | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor XIa light chain, Milvexian | 著者 | Sheriff, S. | 登録日 | 2021-04-01 | 公開日 | 2021-09-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (0.924 Å) | 主引用文献 | Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy. J.Med.Chem., 65, 2022
|
|
8UHL
| ATAD2B bromodomain in complex with histone H4 acetylated at lysine 12 | 分子名称: | ATPase family AAA domain-containing protein 2B, Histone H4 | 著者 | Phillips, M, Montgomery, C, Nix, J.C, Glass, K.C. | 登録日 | 2023-10-09 | 公開日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Impact of Combinatorial Histone Modifications on Acetyllysine Recognition by the ATAD2 and ATAD2B Bromodomains. J.Med.Chem., 67, 2024
|
|
8UK5
| Crystal structure of the bromodomain of human ATAD2B in complex with histone H4S1(ph)K5ac | 分子名称: | ATPase family AAA domain-containing protein 2B, Histone H4S1(ph)K5ac | 著者 | Montgomery, C, Phillips, M, Nix, J.C, Glass, K.C. | 登録日 | 2023-10-12 | 公開日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Impact of Combinatorial Histone Modifications on Acetyllysine Recognition by the ATAD2 and ATAD2B Bromodomains. J.Med.Chem., 67, 2024
|
|
8UR5
| |
8UR7
| |
8IHM
| Eaf3 CHD domain bound to the nucleosome | 分子名称: | Chromatin modification-related protein EAF3, DNA (164-MER), DNA (165-MER), ... | 著者 | Zhang, Y, Gang, C. | 登録日 | 2023-02-23 | 公開日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | 主引用文献 | Structural basis for nucleosome binding and catalysis by the yeast Rpd3S/HDAC holoenzyme. Cell Res., 33, 2023
|
|
8IHN
| Cryo-EM structure of the Rpd3S core complex | 分子名称: | CALCIUM ION, Chromatin modification-related protein EAF3, Histone H3, ... | 著者 | Zhang, Y, Gang, C. | 登録日 | 2023-02-23 | 公開日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | 主引用文献 | Structural basis for nucleosome binding and catalysis by the yeast Rpd3S/HDAC holoenzyme. Cell Res., 33, 2023
|
|
8IHT
| Rpd3S bound to the nucleosome | 分子名称: | CALCIUM ION, Chromatin modification-related protein EAF3, DNA (164-MER), ... | 著者 | Zhang, Y, Gang, C. | 登録日 | 2023-02-23 | 公開日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | 主引用文献 | Structural basis for nucleosome binding and catalysis by the yeast Rpd3S/HDAC holoenzyme. Cell Res., 33, 2023
|
|
8X82
| |
8X83
| |
8X84
| |
4R3B
| |
2I4W
| HIV-1 protease WT with GS-8374 | 分子名称: | DIETHYL ({4-[(2S,3R)-2-({[(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YLOXY]CARBONYL}AMINO)-3-HYDROXY-4-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}BUTYL]PHENOXY}METHYL)PHOSPHONATE, Protease | 著者 | Hatada, M. | 登録日 | 2006-08-22 | 公開日 | 2007-08-28 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Suppression of HIV-1 Protease Inhibitor Resistance by Phosphonate-mediated Solvent Anchoring. J.Mol.Biol., 363, 2006
|
|
2I4U
| HIV-1 protease with TMC-126 | 分子名称: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL [(1S,2R)-1-BENZYL-2-HYDROXY-3-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}PROPYL]CARBAMATE, Protease | 著者 | Hatada, M. | 登録日 | 2006-08-22 | 公開日 | 2007-08-28 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Suppression of HIV-1 Protease Inhibitor Resistance by Phosphonate-mediated Solvent Anchoring. J.Mol.Biol., 363, 2006
|
|
2I4D
| Crystal structure of WT HIV-1 protease with GS-8373 | 分子名称: | ({4-[(2S,3R)-2-({[(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YLOXY]CARBONYL}AMINO)-3-HYDROXY-4-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}BUTYL]PHENOXY}METHYL)PHOSPHONIC ACID, Protease | 著者 | Hatada, M. | 登録日 | 2006-08-21 | 公開日 | 2007-08-21 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Suppression of HIV-1 Protease Inhibitor Resistance by Phosphonate-mediated Solvent Anchoring. J.Mol.Biol., 363, 2006
|
|
2I4V
| HIV-1 protease I84V, L90M with TMC126 | 分子名称: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL [(1S,2R)-1-BENZYL-2-HYDROXY-3-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}PROPYL]CARBAMATE, Protease | 著者 | Hatada, M. | 登録日 | 2006-08-22 | 公開日 | 2007-08-28 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Suppression of HIV-1 Protease Inhibitor Resistance by Phosphonate-mediated Solvent Anchoring. J.Mol.Biol., 363, 2006
|
|
4R8M
| Human SIRT2 crystal structure in complex with BHJH-TM1 | 分子名称: | BHJH-TM1 peptide, NAD-dependent protein deacetylase sirtuin-2, ZINC ION, ... | 著者 | Teng, Y.B, Hao, Q, Lin, H.N, Jing, H. | 登録日 | 2014-09-02 | 公開日 | 2015-03-11 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Efficient Demyristoylase Activity of SIRT2 Revealed by Kinetic and Structural Studies Sci Rep, 5, 2015
|
|
7F8Y
| Crystal structure of the cholecystokinin receptor CCKAR in complex with devazepide | 分子名称: | N-[(3S)-1-methyl-2-oxidanylidene-5-phenyl-3H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide, fusion protein of Cholecystokinin receptor type A and Endolysin | 著者 | Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q. | 登録日 | 2021-07-02 | 公開日 | 2021-10-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structures of the human cholecystokinin receptors bound to agonists and antagonists. Nat.Chem.Biol., 17, 2021
|
|
7F8U
| Crystal structure of the cholecystokinin receptor CCKAR in complex with lintitript | 分子名称: | 2-[2-[[4-(2-chlorophenyl)-1,3-thiazol-2-yl]carbamoyl]indol-1-yl]ethanoic acid, Fusion protein of Cholecystokinin receptor type A and Endolysin | 著者 | Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q. | 登録日 | 2021-07-02 | 公開日 | 2021-10-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structures of the human cholecystokinin receptors bound to agonists and antagonists. Nat.Chem.Biol., 17, 2021
|
|
7F8V
| Cryo-EM structure of the cholecystokinin receptor CCKBR in complex with gastrin-17 and Gi | 分子名称: | Gastrin-17, Gastrin/cholecystokinin type B receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q. | 登録日 | 2021-07-02 | 公開日 | 2021-10-13 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structures of the human cholecystokinin receptors bound to agonists and antagonists. Nat.Chem.Biol., 17, 2021
|
|
7F8W
| Cryo-EM structure of the cholecystokinin receptor CCKBR in complex with gastrin-17 and Gq | 分子名称: | Gastrin-17, Gastrin/cholecystokinin type B receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Zhang, X, He, C, Wang, M, Zhou, Q, Yang, D, Zhu, Y, Wu, B, Zhao, Q. | 登録日 | 2021-07-02 | 公開日 | 2021-10-13 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structures of the human cholecystokinin receptors bound to agonists and antagonists. Nat.Chem.Biol., 17, 2021
|
|