2I4V
HIV-1 protease I84V, L90M with TMC126
Summary for 2I4V
Entry DOI | 10.2210/pdb2i4v/pdb |
Related | 2I4D 2I4U 2I4W 2I4X |
Descriptor | Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL [(1S,2R)-1-BENZYL-2-HYDROXY-3-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}PROPYL]CARBAMATE (3 entities in total) |
Functional Keywords | hiv-1 protein inhibitor mutant, hydrolase |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22234.31 |
Authors | Hatada, M. (deposition date: 2006-08-22, release date: 2007-08-28, Last modification date: 2024-02-21) |
Primary citation | Cihlar, T.,He, G.X.,Liu, X.,Chen, J.M.,Hatada, M.,Swaminathan, S.,McDermott, M.J.,Yang, Z.Y.,Mulato, A.S.,Chen, X.,Leavitt, S.A.,Stray, K.M.,Lee, W.A. Suppression of HIV-1 Protease Inhibitor Resistance by Phosphonate-mediated Solvent Anchoring. J.Mol.Biol., 363:635-647, 2006 Cited by PubMed: 16979654DOI: 10.1016/j.jmb.2006.07.073 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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