2I4D

Crystal structure of WT HIV-1 protease with GS-8373

Summary for 2I4D

Entry DOI	10.2210/pdb2i4d/pdb
Related	2I4U 2I4V 2I4W 2I4X
Descriptor	Protease, ({4-[(2S,3R)-2-({[(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YLOXY]CARBONYL}AMINO)-3-HYDROXY-4-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}BUTYL]PHENOXY}METHYL)PHOSPHONIC ACID (3 entities in total)
Functional Keywords	hiv-1 protease, hydrolase
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	22336.30
Authors	Hatada, M. (deposition date: 2006-08-21, release date: 2007-08-21, Last modification date: 2024-02-21)
Primary citation	Cihlar, T.,He, G.X.,Liu, X.,Chen, J.M.,Hatada, M.,Swaminathan, S.,McDermott, M.J.,Yang, Z.Y.,Mulato, A.S.,Chen, X.,Leavitt, S.A.,Stray, K.M.,Lee, W.A. Suppression of HIV-1 Protease Inhibitor Resistance by Phosphonate-mediated Solvent Anchoring. J.Mol.Biol., 363:635-647, 2006 Cited by PubMed: 16979654 DOI: 10.1016/j.jmb.2006.07.073 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation