2I4D
Crystal structure of WT HIV-1 protease with GS-8373
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Protease | polymer | 99 | 10831.8 | 2 | UniProt (P03368) Pfam (PF00077) UniProt (by SIFTS) (Q5RZ08) In PDB | Human immunodeficiency virus 1 | |
| 2 | B | ({4-[(2S,3R)-2-({[(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YLOXY]CARBONYL}AMINO)-3-HYDROXY-4-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}BUTYL]PHENOXY}METHYL)PHOSPHONIC ACID | non-polymer | 672.7 | 1 | Chemie (QFI) | |||
| 3 | water | water | 18.0 | 174 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03368)
| PDB | External Database | Details |
|---|---|---|
| Met 95 | Cys 594 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21663.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 672.7 | |
| All* | Total formula weight | 22336.3 |
