2I4U

HIV-1 protease with TMC-126

Summary for 2I4U

• Entry DOI: 10.2210/pdb2i4u/pdb
• Related: 2I4D 2I4V 2I4W 2I4X
• Descriptor: Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL [(1S,2R)-1-BENZYL-2-HYDROXY-3-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}PROPYL]CARBAMATE (3 entities in total)
• Functional Keywords: protein inhibitor complex, hydrolase
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 2
• Total formula weight: 22226.29

Authors

Hatada, M. (deposition date: 2006-08-22, release date: 2007-08-28, Last modification date: 2024-02-21)

• Primary citation: Cihlar, T.,He, G.X.,Liu, X.,Chen, J.M.,Hatada, M.,Swaminathan, S.,McDermott, M.J.,Yang, Z.Y.,Mulato, A.S.,Chen, X.,Leavitt, S.A.,Stray, K.M.,Lee, W.A.; Suppression of HIV-1 Protease Inhibitor Resistance by Phosphonate-mediated Solvent Anchoring.; J.Mol.Biol., 363:635-647, 2006; PubMed: 16979654; DOI: 10.1016/j.jmb.2006.07.073

Experimental method

X-RAY DIFFRACTION (1.5 Å)