2I4U
HIV-1 protease with TMC-126
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Protease | polymer | 99 | 10831.8 | 2 | UniProt (P03368) Pfam (PF00077) UniProt (by SIFTS) (P03366) | Human immunodeficiency virus 1 | |
| 2 | C (A) | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL [(1S,2R)-1-BENZYL-2-HYDROXY-3-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}PROPYL]CARBAMATE | non-polymer | 562.7 | 1 | Chemie (DJR) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 172 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03368)
| PDB | External Database | Details |
|---|---|---|
| Met 95 | Cys 594 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21663.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 562.7 | |
| All* | Total formula weight | 22226.3 |
