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4R8M

Human SIRT2 crystal structure in complex with BHJH-TM1

Summary for 4R8M
Entry DOI10.2210/pdb4r8m/pdb
Related3PKJ 3ZGO 3ZGV 4L3O
DescriptorNAD-dependent protein deacetylase sirtuin-2, BHJH-TM1 peptide, ZINC ION, ... (5 entities in total)
Functional Keywordsrossmann fold, nad-dependent protein deacetylase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
More
Cellular locationNucleus. Isoform 1: Cytoplasm . Isoform 2: Cytoplasm . Isoform 5: Cytoplasm : Q8IXJ6
Total number of polymer chains4
Total formula weight73942.36
Authors
Teng, Y.B.,Hao, Q.,Lin, H.N.,Jing, H. (deposition date: 2014-09-02, release date: 2015-03-11, Last modification date: 2023-11-08)
Primary citationTeng, Y.B.,Jing, H.,Aramsangtienchai, P.,He, B.,Khan, S.,Hu, J.,Lin, H.,Hao, Q.
Efficient Demyristoylase Activity of SIRT2 Revealed by Kinetic and Structural Studies
Sci Rep, 5:8529-8529, 2015
Cited by
PubMed: 25704306
DOI: 10.1038/srep08529
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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