3PKJ

Human SIRT6 crystal structure in complex with 2'-N-Acetyl ADP ribose

Summary for 3PKJ

• Entry DOI: 10.2210/pdb3pkj/pdb
• Related: 3K35 3PKI
• Descriptor: NAD-dependent deacetylase sirtuin-6, [(2R,3S,4R,5R)-4-(acetylamino)-3,5-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate, ZINC ION, ... (6 entities in total)
• Functional Keywords: rossmann fold, zn-binding domain, structural genomics, structural genomics consortium, sgc, adp-ribosylation, 2'-n-acetyl adp ribose, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus, nucleoplasm : Q8N6T7
• Total number of polymer chains: 6
• Total formula weight: 239787.66

Authors

Pan, P.W.,Dong, A.,Qiu, W.,Loppnau, P.,Wang, J.,Ravichandran, M.,Walker, J.R.,Bountra, C.,Weigelt, J.,Arrowsmith, C.H.,Min, J.,Edwards, A.M.,Structural Genomics Consortium (SGC) (deposition date: 2010-11-11, release date: 2011-01-26, Last modification date: 2023-09-06)

• Primary citation: Pan, P.W.,Feldman, J.L.,Devries, M.K.,Dong, A.,Edwards, A.M.,Denu, J.M.; Structure and biochemical functions of SIRT6.; J.Biol.Chem., 286:14575-14587, 2011; PubMed: 21362626; DOI: 10.1074/jbc.M111.218990

Experimental method

X-RAY DIFFRACTION (2.12 Å)