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3PKJ

Human SIRT6 crystal structure in complex with 2'-N-Acetyl ADP ribose

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000781cellular_componentchromosome, telomeric region
A0000785cellular_componentchromatin
A0003677molecular_functionDNA binding
A0003682molecular_functionchromatin binding
A0003684molecular_functiondamaged DNA binding
A0003714molecular_functiontranscription corepressor activity
A0003723molecular_functionRNA binding
A0003950molecular_functionNAD+ poly-ADP-ribosyltransferase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0005721cellular_componentpericentric heterochromatin
A0005730cellular_componentnucleolus
A0005783cellular_componentendoplasmic reticulum
A0006094biological_processgluconeogenesis
A0006096biological_processglycolytic process
A0006111biological_processregulation of gluconeogenesis
A0006281biological_processDNA repair
A0006282biological_processregulation of DNA repair
A0006284biological_processbase-excision repair
A0006302biological_processdouble-strand break repair
A0006325biological_processchromatin organization
A0006338biological_processchromatin remodeling
A0006476biological_processprotein deacetylation
A0006606biological_processprotein import into nucleus
A0006954biological_processinflammatory response
A0006974biological_processDNA damage response
A0007265biological_processRas protein signal transduction
A0008270molecular_functionzinc ion binding
A0008285biological_processnegative regulation of cell population proliferation
A0008340biological_processdetermination of adult lifespan
A0009411biological_processresponse to UV
A0010526biological_processtransposable element silencing
A0010569biological_processregulation of double-strand break repair via homologous recombination
A0016740molecular_functiontransferase activity
A0016746molecular_functionacyltransferase activity
A0016757molecular_functionglycosyltransferase activity
A0016779molecular_functionnucleotidyltransferase activity
A0017136molecular_functionhistone deacetylase activity, NAD-dependent
A0019216biological_processregulation of lipid metabolic process
A0030234molecular_functionenzyme regulator activity
A0031490molecular_functionchromatin DNA binding
A0031491molecular_functionnucleosome binding
A0031508biological_processpericentric heterochromatin formation
A0031509biological_processsubtelomeric heterochromatin formation
A0031648biological_processprotein destabilization
A0032024biological_processpositive regulation of insulin secretion
A0032129molecular_functionhistone H3K9 deacetylase activity, hydrolytic mechanism
A0032206biological_processpositive regulation of telomere maintenance
A0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
A0032922biological_processcircadian regulation of gene expression
A0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
A0034979molecular_functionNAD-dependent protein lysine deacetylase activity
A0035033molecular_functionhistone deacetylase regulator activity
A0035861cellular_componentsite of double-strand break
A0042181biological_processketone biosynthetic process
A0042308biological_processnegative regulation of protein import into nucleus
A0042593biological_processglucose homeostasis
A0042752biological_processregulation of circadian rhythm
A0042803molecular_functionprotein homodimerization activity
A0045600biological_processpositive regulation of fat cell differentiation
A0045721biological_processnegative regulation of gluconeogenesis
A0045722biological_processpositive regulation of gluconeogenesis
A0045814biological_processnegative regulation of gene expression, epigenetic
A0045820biological_processnegative regulation of glycolytic process
A0045892biological_processnegative regulation of DNA-templated transcription
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046325biological_processnegative regulation of D-glucose import
A0046827biological_processpositive regulation of protein export from nucleus
A0046872molecular_functionmetal ion binding
A0046969molecular_functionhistone H3K9 deacetylase activity, NAD-dependent
A0048146biological_processpositive regulation of fibroblast proliferation
A0050708biological_processregulation of protein secretion
A0050994biological_processregulation of lipid catabolic process
A0051697biological_processprotein delipidation
A0055007biological_processcardiac muscle cell differentiation
A0070212biological_processprotein poly-ADP-ribosylation
A0070403molecular_functionNAD+ binding
A0090734cellular_componentsite of DNA damage
A0097372molecular_functionhistone H3K18 deacetylase activity, NAD-dependent
A0099115cellular_componentchromosome, subtelomeric region
A0106222molecular_functionlncRNA binding
A0106274molecular_functionNAD+-protein-arginine ADP-ribosyltransferase activity
A0120162biological_processpositive regulation of cold-induced thermogenesis
A0120186biological_processnegative regulation of protein localization to chromatin
A0120187biological_processpositive regulation of protein localization to chromatin
A0140612molecular_functionDNA damage sensor activity
A0140765molecular_functionhistone H3K56 deacetylase activity, NAD-dependent
A0140773molecular_functionNAD-dependent protein demyristoylase activity
A0140774molecular_functionNAD-dependent protein depalmitoylase activity
A0140804molecular_functionNAD+-protein-lysine ADP-ribosyltransferase activity
A0140861biological_processDNA repair-dependent chromatin remodeling
A0160239biological_processtranscription pausing by RNA polymerase II
A1902459biological_processpositive regulation of stem cell population maintenance
A1902732biological_processpositive regulation of chondrocyte proliferation
A1903076biological_processregulation of protein localization to plasma membrane
A1904841molecular_functionTORC2 complex binding
A1905555biological_processpositive regulation of blood vessel branching
A1905564biological_processpositive regulation of vascular endothelial cell proliferation
A1990166biological_processprotein localization to site of double-strand break
A1990404molecular_functionNAD+-protein mono-ADP-ribosyltransferase activity
A2000648biological_processpositive regulation of stem cell proliferation
A2000738biological_processpositive regulation of stem cell differentiation
A2000773biological_processnegative regulation of cellular senescence
A2000774biological_processpositive regulation of cellular senescence
A2000781biological_processpositive regulation of double-strand break repair
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000781cellular_componentchromosome, telomeric region
B0000785cellular_componentchromatin
B0003677molecular_functionDNA binding
B0003682molecular_functionchromatin binding
B0003684molecular_functiondamaged DNA binding
B0003714molecular_functiontranscription corepressor activity
B0003723molecular_functionRNA binding
B0003950molecular_functionNAD+ poly-ADP-ribosyltransferase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005694cellular_componentchromosome
B0005721cellular_componentpericentric heterochromatin
B0005730cellular_componentnucleolus
B0005783cellular_componentendoplasmic reticulum
B0006094biological_processgluconeogenesis
B0006096biological_processglycolytic process
B0006111biological_processregulation of gluconeogenesis
B0006281biological_processDNA repair
B0006282biological_processregulation of DNA repair
B0006284biological_processbase-excision repair
B0006302biological_processdouble-strand break repair
B0006325biological_processchromatin organization
B0006338biological_processchromatin remodeling
B0006476biological_processprotein deacetylation
B0006606biological_processprotein import into nucleus
B0006954biological_processinflammatory response
B0006974biological_processDNA damage response
B0007265biological_processRas protein signal transduction
B0008270molecular_functionzinc ion binding
B0008285biological_processnegative regulation of cell population proliferation
B0008340biological_processdetermination of adult lifespan
B0009411biological_processresponse to UV
B0010526biological_processtransposable element silencing
B0010569biological_processregulation of double-strand break repair via homologous recombination
B0016740molecular_functiontransferase activity
B0016746molecular_functionacyltransferase activity
B0016757molecular_functionglycosyltransferase activity
B0016779molecular_functionnucleotidyltransferase activity
B0017136molecular_functionhistone deacetylase activity, NAD-dependent
B0019216biological_processregulation of lipid metabolic process
B0030234molecular_functionenzyme regulator activity
B0031490molecular_functionchromatin DNA binding
B0031491molecular_functionnucleosome binding
B0031508biological_processpericentric heterochromatin formation
B0031509biological_processsubtelomeric heterochromatin formation
B0031648biological_processprotein destabilization
B0032024biological_processpositive regulation of insulin secretion
B0032129molecular_functionhistone H3K9 deacetylase activity, hydrolytic mechanism
B0032206biological_processpositive regulation of telomere maintenance
B0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
B0032922biological_processcircadian regulation of gene expression
B0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
B0034979molecular_functionNAD-dependent protein lysine deacetylase activity
B0035033molecular_functionhistone deacetylase regulator activity
B0035861cellular_componentsite of double-strand break
B0042181biological_processketone biosynthetic process
B0042308biological_processnegative regulation of protein import into nucleus
B0042593biological_processglucose homeostasis
B0042752biological_processregulation of circadian rhythm
B0042803molecular_functionprotein homodimerization activity
B0045600biological_processpositive regulation of fat cell differentiation
B0045721biological_processnegative regulation of gluconeogenesis
B0045722biological_processpositive regulation of gluconeogenesis
B0045814biological_processnegative regulation of gene expression, epigenetic
B0045820biological_processnegative regulation of glycolytic process
B0045892biological_processnegative regulation of DNA-templated transcription
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046325biological_processnegative regulation of D-glucose import
B0046827biological_processpositive regulation of protein export from nucleus
B0046872molecular_functionmetal ion binding
B0046969molecular_functionhistone H3K9 deacetylase activity, NAD-dependent
B0048146biological_processpositive regulation of fibroblast proliferation
B0050708biological_processregulation of protein secretion
B0050994biological_processregulation of lipid catabolic process
B0051697biological_processprotein delipidation
B0055007biological_processcardiac muscle cell differentiation
B0070212biological_processprotein poly-ADP-ribosylation
B0070403molecular_functionNAD+ binding
B0090734cellular_componentsite of DNA damage
B0097372molecular_functionhistone H3K18 deacetylase activity, NAD-dependent
B0099115cellular_componentchromosome, subtelomeric region
B0106222molecular_functionlncRNA binding
B0106274molecular_functionNAD+-protein-arginine ADP-ribosyltransferase activity
B0120162biological_processpositive regulation of cold-induced thermogenesis
B0120186biological_processnegative regulation of protein localization to chromatin
B0120187biological_processpositive regulation of protein localization to chromatin
B0140612molecular_functionDNA damage sensor activity
B0140765molecular_functionhistone H3K56 deacetylase activity, NAD-dependent
B0140773molecular_functionNAD-dependent protein demyristoylase activity
B0140774molecular_functionNAD-dependent protein depalmitoylase activity
B0140804molecular_functionNAD+-protein-lysine ADP-ribosyltransferase activity
B0140861biological_processDNA repair-dependent chromatin remodeling
B0160239biological_processtranscription pausing by RNA polymerase II
B1902459biological_processpositive regulation of stem cell population maintenance
B1902732biological_processpositive regulation of chondrocyte proliferation
B1903076biological_processregulation of protein localization to plasma membrane
B1904841molecular_functionTORC2 complex binding
B1905555biological_processpositive regulation of blood vessel branching
B1905564biological_processpositive regulation of vascular endothelial cell proliferation
B1990166biological_processprotein localization to site of double-strand break
B1990404molecular_functionNAD+-protein mono-ADP-ribosyltransferase activity
B2000648biological_processpositive regulation of stem cell proliferation
B2000738biological_processpositive regulation of stem cell differentiation
B2000773biological_processnegative regulation of cellular senescence
B2000774biological_processpositive regulation of cellular senescence
B2000781biological_processpositive regulation of double-strand break repair
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000781cellular_componentchromosome, telomeric region
C0000785cellular_componentchromatin
C0003677molecular_functionDNA binding
C0003682molecular_functionchromatin binding
C0003684molecular_functiondamaged DNA binding
C0003714molecular_functiontranscription corepressor activity
C0003723molecular_functionRNA binding
C0003950molecular_functionNAD+ poly-ADP-ribosyltransferase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005694cellular_componentchromosome
C0005721cellular_componentpericentric heterochromatin
C0005730cellular_componentnucleolus
C0005783cellular_componentendoplasmic reticulum
C0006094biological_processgluconeogenesis
C0006096biological_processglycolytic process
C0006111biological_processregulation of gluconeogenesis
C0006281biological_processDNA repair
C0006282biological_processregulation of DNA repair
C0006284biological_processbase-excision repair
C0006302biological_processdouble-strand break repair
C0006325biological_processchromatin organization
C0006338biological_processchromatin remodeling
C0006476biological_processprotein deacetylation
C0006606biological_processprotein import into nucleus
C0006954biological_processinflammatory response
C0006974biological_processDNA damage response
C0007265biological_processRas protein signal transduction
C0008270molecular_functionzinc ion binding
C0008285biological_processnegative regulation of cell population proliferation
C0008340biological_processdetermination of adult lifespan
C0009411biological_processresponse to UV
C0010526biological_processtransposable element silencing
C0010569biological_processregulation of double-strand break repair via homologous recombination
C0016740molecular_functiontransferase activity
C0016746molecular_functionacyltransferase activity
C0016757molecular_functionglycosyltransferase activity
C0016779molecular_functionnucleotidyltransferase activity
C0017136molecular_functionhistone deacetylase activity, NAD-dependent
C0019216biological_processregulation of lipid metabolic process
C0030234molecular_functionenzyme regulator activity
C0031490molecular_functionchromatin DNA binding
C0031491molecular_functionnucleosome binding
C0031508biological_processpericentric heterochromatin formation
C0031509biological_processsubtelomeric heterochromatin formation
C0031648biological_processprotein destabilization
C0032024biological_processpositive regulation of insulin secretion
C0032129molecular_functionhistone H3K9 deacetylase activity, hydrolytic mechanism
C0032206biological_processpositive regulation of telomere maintenance
C0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
C0032922biological_processcircadian regulation of gene expression
C0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
C0034979molecular_functionNAD-dependent protein lysine deacetylase activity
C0035033molecular_functionhistone deacetylase regulator activity
C0035861cellular_componentsite of double-strand break
C0042181biological_processketone biosynthetic process
C0042308biological_processnegative regulation of protein import into nucleus
C0042593biological_processglucose homeostasis
C0042752biological_processregulation of circadian rhythm
C0042803molecular_functionprotein homodimerization activity
C0045600biological_processpositive regulation of fat cell differentiation
C0045721biological_processnegative regulation of gluconeogenesis
C0045722biological_processpositive regulation of gluconeogenesis
C0045814biological_processnegative regulation of gene expression, epigenetic
C0045820biological_processnegative regulation of glycolytic process
C0045892biological_processnegative regulation of DNA-templated transcription
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0046325biological_processnegative regulation of D-glucose import
C0046827biological_processpositive regulation of protein export from nucleus
C0046872molecular_functionmetal ion binding
C0046969molecular_functionhistone H3K9 deacetylase activity, NAD-dependent
C0048146biological_processpositive regulation of fibroblast proliferation
C0050708biological_processregulation of protein secretion
C0050994biological_processregulation of lipid catabolic process
C0051697biological_processprotein delipidation
C0055007biological_processcardiac muscle cell differentiation
C0070212biological_processprotein poly-ADP-ribosylation
C0070403molecular_functionNAD+ binding
C0090734cellular_componentsite of DNA damage
C0097372molecular_functionhistone H3K18 deacetylase activity, NAD-dependent
C0099115cellular_componentchromosome, subtelomeric region
C0106222molecular_functionlncRNA binding
C0106274molecular_functionNAD+-protein-arginine ADP-ribosyltransferase activity
C0120162biological_processpositive regulation of cold-induced thermogenesis
C0120186biological_processnegative regulation of protein localization to chromatin
C0120187biological_processpositive regulation of protein localization to chromatin
C0140612molecular_functionDNA damage sensor activity
C0140765molecular_functionhistone H3K56 deacetylase activity, NAD-dependent
C0140773molecular_functionNAD-dependent protein demyristoylase activity
C0140774molecular_functionNAD-dependent protein depalmitoylase activity
C0140804molecular_functionNAD+-protein-lysine ADP-ribosyltransferase activity
C0140861biological_processDNA repair-dependent chromatin remodeling
C0160239biological_processtranscription pausing by RNA polymerase II
C1902459biological_processpositive regulation of stem cell population maintenance
C1902732biological_processpositive regulation of chondrocyte proliferation
C1903076biological_processregulation of protein localization to plasma membrane
C1904841molecular_functionTORC2 complex binding
C1905555biological_processpositive regulation of blood vessel branching
C1905564biological_processpositive regulation of vascular endothelial cell proliferation
C1990166biological_processprotein localization to site of double-strand break
C1990404molecular_functionNAD+-protein mono-ADP-ribosyltransferase activity
C2000648biological_processpositive regulation of stem cell proliferation
C2000738biological_processpositive regulation of stem cell differentiation
C2000773biological_processnegative regulation of cellular senescence
C2000774biological_processpositive regulation of cellular senescence
C2000781biological_processpositive regulation of double-strand break repair
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000781cellular_componentchromosome, telomeric region
D0000785cellular_componentchromatin
D0003677molecular_functionDNA binding
D0003682molecular_functionchromatin binding
D0003684molecular_functiondamaged DNA binding
D0003714molecular_functiontranscription corepressor activity
D0003723molecular_functionRNA binding
D0003950molecular_functionNAD+ poly-ADP-ribosyltransferase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005694cellular_componentchromosome
D0005721cellular_componentpericentric heterochromatin
D0005730cellular_componentnucleolus
D0005783cellular_componentendoplasmic reticulum
D0006094biological_processgluconeogenesis
D0006096biological_processglycolytic process
D0006111biological_processregulation of gluconeogenesis
D0006281biological_processDNA repair
D0006282biological_processregulation of DNA repair
D0006284biological_processbase-excision repair
D0006302biological_processdouble-strand break repair
D0006325biological_processchromatin organization
D0006338biological_processchromatin remodeling
D0006476biological_processprotein deacetylation
D0006606biological_processprotein import into nucleus
D0006954biological_processinflammatory response
D0006974biological_processDNA damage response
D0007265biological_processRas protein signal transduction
D0008270molecular_functionzinc ion binding
D0008285biological_processnegative regulation of cell population proliferation
D0008340biological_processdetermination of adult lifespan
D0009411biological_processresponse to UV
D0010526biological_processtransposable element silencing
D0010569biological_processregulation of double-strand break repair via homologous recombination
D0016740molecular_functiontransferase activity
D0016746molecular_functionacyltransferase activity
D0016757molecular_functionglycosyltransferase activity
D0016779molecular_functionnucleotidyltransferase activity
D0017136molecular_functionhistone deacetylase activity, NAD-dependent
D0019216biological_processregulation of lipid metabolic process
D0030234molecular_functionenzyme regulator activity
D0031490molecular_functionchromatin DNA binding
D0031491molecular_functionnucleosome binding
D0031508biological_processpericentric heterochromatin formation
D0031509biological_processsubtelomeric heterochromatin formation
D0031648biological_processprotein destabilization
D0032024biological_processpositive regulation of insulin secretion
D0032129molecular_functionhistone H3K9 deacetylase activity, hydrolytic mechanism
D0032206biological_processpositive regulation of telomere maintenance
D0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
D0032922biological_processcircadian regulation of gene expression
D0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
D0034979molecular_functionNAD-dependent protein lysine deacetylase activity
D0035033molecular_functionhistone deacetylase regulator activity
D0035861cellular_componentsite of double-strand break
D0042181biological_processketone biosynthetic process
D0042308biological_processnegative regulation of protein import into nucleus
D0042593biological_processglucose homeostasis
D0042752biological_processregulation of circadian rhythm
D0042803molecular_functionprotein homodimerization activity
D0045600biological_processpositive regulation of fat cell differentiation
D0045721biological_processnegative regulation of gluconeogenesis
D0045722biological_processpositive regulation of gluconeogenesis
D0045814biological_processnegative regulation of gene expression, epigenetic
D0045820biological_processnegative regulation of glycolytic process
D0045892biological_processnegative regulation of DNA-templated transcription
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046325biological_processnegative regulation of D-glucose import
D0046827biological_processpositive regulation of protein export from nucleus
D0046872molecular_functionmetal ion binding
D0046969molecular_functionhistone H3K9 deacetylase activity, NAD-dependent
D0048146biological_processpositive regulation of fibroblast proliferation
D0050708biological_processregulation of protein secretion
D0050994biological_processregulation of lipid catabolic process
D0051697biological_processprotein delipidation
D0055007biological_processcardiac muscle cell differentiation
D0070212biological_processprotein poly-ADP-ribosylation
D0070403molecular_functionNAD+ binding
D0090734cellular_componentsite of DNA damage
D0097372molecular_functionhistone H3K18 deacetylase activity, NAD-dependent
D0099115cellular_componentchromosome, subtelomeric region
D0106222molecular_functionlncRNA binding
D0106274molecular_functionNAD+-protein-arginine ADP-ribosyltransferase activity
D0120162biological_processpositive regulation of cold-induced thermogenesis
D0120186biological_processnegative regulation of protein localization to chromatin
D0120187biological_processpositive regulation of protein localization to chromatin
D0140612molecular_functionDNA damage sensor activity
D0140765molecular_functionhistone H3K56 deacetylase activity, NAD-dependent
D0140773molecular_functionNAD-dependent protein demyristoylase activity
D0140774molecular_functionNAD-dependent protein depalmitoylase activity
D0140804molecular_functionNAD+-protein-lysine ADP-ribosyltransferase activity
D0140861biological_processDNA repair-dependent chromatin remodeling
D0160239biological_processtranscription pausing by RNA polymerase II
D1902459biological_processpositive regulation of stem cell population maintenance
D1902732biological_processpositive regulation of chondrocyte proliferation
D1903076biological_processregulation of protein localization to plasma membrane
D1904841molecular_functionTORC2 complex binding
D1905555biological_processpositive regulation of blood vessel branching
D1905564biological_processpositive regulation of vascular endothelial cell proliferation
D1990166biological_processprotein localization to site of double-strand break
D1990404molecular_functionNAD+-protein mono-ADP-ribosyltransferase activity
D2000648biological_processpositive regulation of stem cell proliferation
D2000738biological_processpositive regulation of stem cell differentiation
D2000773biological_processnegative regulation of cellular senescence
D2000774biological_processpositive regulation of cellular senescence
D2000781biological_processpositive regulation of double-strand break repair
E0000122biological_processnegative regulation of transcription by RNA polymerase II
E0000781cellular_componentchromosome, telomeric region
E0000785cellular_componentchromatin
E0003677molecular_functionDNA binding
E0003682molecular_functionchromatin binding
E0003684molecular_functiondamaged DNA binding
E0003714molecular_functiontranscription corepressor activity
E0003723molecular_functionRNA binding
E0003950molecular_functionNAD+ poly-ADP-ribosyltransferase activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005694cellular_componentchromosome
E0005721cellular_componentpericentric heterochromatin
E0005730cellular_componentnucleolus
E0005783cellular_componentendoplasmic reticulum
E0006094biological_processgluconeogenesis
E0006096biological_processglycolytic process
E0006111biological_processregulation of gluconeogenesis
E0006281biological_processDNA repair
E0006282biological_processregulation of DNA repair
E0006284biological_processbase-excision repair
E0006302biological_processdouble-strand break repair
E0006325biological_processchromatin organization
E0006338biological_processchromatin remodeling
E0006476biological_processprotein deacetylation
E0006606biological_processprotein import into nucleus
E0006954biological_processinflammatory response
E0006974biological_processDNA damage response
E0007265biological_processRas protein signal transduction
E0008270molecular_functionzinc ion binding
E0008285biological_processnegative regulation of cell population proliferation
E0008340biological_processdetermination of adult lifespan
E0009411biological_processresponse to UV
E0010526biological_processtransposable element silencing
E0010569biological_processregulation of double-strand break repair via homologous recombination
E0016740molecular_functiontransferase activity
E0016746molecular_functionacyltransferase activity
E0016757molecular_functionglycosyltransferase activity
E0016779molecular_functionnucleotidyltransferase activity
E0017136molecular_functionhistone deacetylase activity, NAD-dependent
E0019216biological_processregulation of lipid metabolic process
E0030234molecular_functionenzyme regulator activity
E0031490molecular_functionchromatin DNA binding
E0031491molecular_functionnucleosome binding
E0031508biological_processpericentric heterochromatin formation
E0031509biological_processsubtelomeric heterochromatin formation
E0031648biological_processprotein destabilization
E0032024biological_processpositive regulation of insulin secretion
E0032129molecular_functionhistone H3K9 deacetylase activity, hydrolytic mechanism
E0032206biological_processpositive regulation of telomere maintenance
E0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
E0032922biological_processcircadian regulation of gene expression
E0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
E0034979molecular_functionNAD-dependent protein lysine deacetylase activity
E0035033molecular_functionhistone deacetylase regulator activity
E0035861cellular_componentsite of double-strand break
E0042181biological_processketone biosynthetic process
E0042308biological_processnegative regulation of protein import into nucleus
E0042593biological_processglucose homeostasis
E0042752biological_processregulation of circadian rhythm
E0042803molecular_functionprotein homodimerization activity
E0045600biological_processpositive regulation of fat cell differentiation
E0045721biological_processnegative regulation of gluconeogenesis
E0045722biological_processpositive regulation of gluconeogenesis
E0045814biological_processnegative regulation of gene expression, epigenetic
E0045820biological_processnegative regulation of glycolytic process
E0045892biological_processnegative regulation of DNA-templated transcription
E0045944biological_processpositive regulation of transcription by RNA polymerase II
E0046325biological_processnegative regulation of D-glucose import
E0046827biological_processpositive regulation of protein export from nucleus
E0046872molecular_functionmetal ion binding
E0046969molecular_functionhistone H3K9 deacetylase activity, NAD-dependent
E0048146biological_processpositive regulation of fibroblast proliferation
E0050708biological_processregulation of protein secretion
E0050994biological_processregulation of lipid catabolic process
E0051697biological_processprotein delipidation
E0055007biological_processcardiac muscle cell differentiation
E0070212biological_processprotein poly-ADP-ribosylation
E0070403molecular_functionNAD+ binding
E0090734cellular_componentsite of DNA damage
E0097372molecular_functionhistone H3K18 deacetylase activity, NAD-dependent
E0099115cellular_componentchromosome, subtelomeric region
E0106222molecular_functionlncRNA binding
E0106274molecular_functionNAD+-protein-arginine ADP-ribosyltransferase activity
E0120162biological_processpositive regulation of cold-induced thermogenesis
E0120186biological_processnegative regulation of protein localization to chromatin
E0120187biological_processpositive regulation of protein localization to chromatin
E0140612molecular_functionDNA damage sensor activity
E0140765molecular_functionhistone H3K56 deacetylase activity, NAD-dependent
E0140773molecular_functionNAD-dependent protein demyristoylase activity
E0140774molecular_functionNAD-dependent protein depalmitoylase activity
E0140804molecular_functionNAD+-protein-lysine ADP-ribosyltransferase activity
E0140861biological_processDNA repair-dependent chromatin remodeling
E0160239biological_processtranscription pausing by RNA polymerase II
E1902459biological_processpositive regulation of stem cell population maintenance
E1902732biological_processpositive regulation of chondrocyte proliferation
E1903076biological_processregulation of protein localization to plasma membrane
E1904841molecular_functionTORC2 complex binding
E1905555biological_processpositive regulation of blood vessel branching
E1905564biological_processpositive regulation of vascular endothelial cell proliferation
E1990166biological_processprotein localization to site of double-strand break
E1990404molecular_functionNAD+-protein mono-ADP-ribosyltransferase activity
E2000648biological_processpositive regulation of stem cell proliferation
E2000738biological_processpositive regulation of stem cell differentiation
E2000773biological_processnegative regulation of cellular senescence
E2000774biological_processpositive regulation of cellular senescence
E2000781biological_processpositive regulation of double-strand break repair
F0000122biological_processnegative regulation of transcription by RNA polymerase II
F0000781cellular_componentchromosome, telomeric region
F0000785cellular_componentchromatin
F0003677molecular_functionDNA binding
F0003682molecular_functionchromatin binding
F0003684molecular_functiondamaged DNA binding
F0003714molecular_functiontranscription corepressor activity
F0003723molecular_functionRNA binding
F0003950molecular_functionNAD+ poly-ADP-ribosyltransferase activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005694cellular_componentchromosome
F0005721cellular_componentpericentric heterochromatin
F0005730cellular_componentnucleolus
F0005783cellular_componentendoplasmic reticulum
F0006094biological_processgluconeogenesis
F0006096biological_processglycolytic process
F0006111biological_processregulation of gluconeogenesis
F0006281biological_processDNA repair
F0006282biological_processregulation of DNA repair
F0006284biological_processbase-excision repair
F0006302biological_processdouble-strand break repair
F0006325biological_processchromatin organization
F0006338biological_processchromatin remodeling
F0006476biological_processprotein deacetylation
F0006606biological_processprotein import into nucleus
F0006954biological_processinflammatory response
F0006974biological_processDNA damage response
F0007265biological_processRas protein signal transduction
F0008270molecular_functionzinc ion binding
F0008285biological_processnegative regulation of cell population proliferation
F0008340biological_processdetermination of adult lifespan
F0009411biological_processresponse to UV
F0010526biological_processtransposable element silencing
F0010569biological_processregulation of double-strand break repair via homologous recombination
F0016740molecular_functiontransferase activity
F0016746molecular_functionacyltransferase activity
F0016757molecular_functionglycosyltransferase activity
F0016779molecular_functionnucleotidyltransferase activity
F0017136molecular_functionhistone deacetylase activity, NAD-dependent
F0019216biological_processregulation of lipid metabolic process
F0030234molecular_functionenzyme regulator activity
F0031490molecular_functionchromatin DNA binding
F0031491molecular_functionnucleosome binding
F0031508biological_processpericentric heterochromatin formation
F0031509biological_processsubtelomeric heterochromatin formation
F0031648biological_processprotein destabilization
F0032024biological_processpositive regulation of insulin secretion
F0032129molecular_functionhistone H3K9 deacetylase activity, hydrolytic mechanism
F0032206biological_processpositive regulation of telomere maintenance
F0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
F0032922biological_processcircadian regulation of gene expression
F0034244biological_processnegative regulation of transcription elongation by RNA polymerase II
F0034979molecular_functionNAD-dependent protein lysine deacetylase activity
F0035033molecular_functionhistone deacetylase regulator activity
F0035861cellular_componentsite of double-strand break
F0042181biological_processketone biosynthetic process
F0042308biological_processnegative regulation of protein import into nucleus
F0042593biological_processglucose homeostasis
F0042752biological_processregulation of circadian rhythm
F0042803molecular_functionprotein homodimerization activity
F0045600biological_processpositive regulation of fat cell differentiation
F0045721biological_processnegative regulation of gluconeogenesis
F0045722biological_processpositive regulation of gluconeogenesis
F0045814biological_processnegative regulation of gene expression, epigenetic
F0045820biological_processnegative regulation of glycolytic process
F0045892biological_processnegative regulation of DNA-templated transcription
F0045944biological_processpositive regulation of transcription by RNA polymerase II
F0046325biological_processnegative regulation of D-glucose import
F0046827biological_processpositive regulation of protein export from nucleus
F0046872molecular_functionmetal ion binding
F0046969molecular_functionhistone H3K9 deacetylase activity, NAD-dependent
F0048146biological_processpositive regulation of fibroblast proliferation
F0050708biological_processregulation of protein secretion
F0050994biological_processregulation of lipid catabolic process
F0051697biological_processprotein delipidation
F0055007biological_processcardiac muscle cell differentiation
F0070212biological_processprotein poly-ADP-ribosylation
F0070403molecular_functionNAD+ binding
F0090734cellular_componentsite of DNA damage
F0097372molecular_functionhistone H3K18 deacetylase activity, NAD-dependent
F0099115cellular_componentchromosome, subtelomeric region
F0106222molecular_functionlncRNA binding
F0106274molecular_functionNAD+-protein-arginine ADP-ribosyltransferase activity
F0120162biological_processpositive regulation of cold-induced thermogenesis
F0120186biological_processnegative regulation of protein localization to chromatin
F0120187biological_processpositive regulation of protein localization to chromatin
F0140612molecular_functionDNA damage sensor activity
F0140765molecular_functionhistone H3K56 deacetylase activity, NAD-dependent
F0140773molecular_functionNAD-dependent protein demyristoylase activity
F0140774molecular_functionNAD-dependent protein depalmitoylase activity
F0140804molecular_functionNAD+-protein-lysine ADP-ribosyltransferase activity
F0140861biological_processDNA repair-dependent chromatin remodeling
F0160239biological_processtranscription pausing by RNA polymerase II
F1902459biological_processpositive regulation of stem cell population maintenance
F1902732biological_processpositive regulation of chondrocyte proliferation
F1903076biological_processregulation of protein localization to plasma membrane
F1904841molecular_functionTORC2 complex binding
F1905555biological_processpositive regulation of blood vessel branching
F1905564biological_processpositive regulation of vascular endothelial cell proliferation
F1990166biological_processprotein localization to site of double-strand break
F1990404molecular_functionNAD+-protein mono-ADP-ribosyltransferase activity
F2000648biological_processpositive regulation of stem cell proliferation
F2000738biological_processpositive regulation of stem cell differentiation
F2000773biological_processnegative regulation of cellular senescence
F2000774biological_processpositive regulation of cellular senescence
F2000781biological_processpositive regulation of double-strand break repair
Functional Information from PDB Data
site_idAC1
Number of Residues23
DetailsBINDING SITE FOR RESIDUE A2N A 1000
ChainResidue
AGLY50
AHIS131
ALEU184
ATRP186
AGLY212
ATHR213
ASER214
AILE217
AASN238
ALEU239
AGLN240
AALA51
AGLY254
ATYR255
AVAL256
AHOH428
AGLY52
ATHR55
AASP61
APHE62
AARG63
ATRP69
AGLN111

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 354
ChainResidue
ACYS139
ACYS142
ACYS164
ACYS175

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 1008
ChainResidue
ALYS31
AARG251
AHIS253

site_idAC4
Number of Residues23
DetailsBINDING SITE FOR RESIDUE A2N B 1000
ChainResidue
BGLY50
BALA51
BGLY52
BTHR55
BASP61
BPHE62
BARG63
BTRP69
BGLN111
BHIS131
BLEU184
BGLY212
BTHR213
BSER214
BILE217
BASN238
BLEU239
BGLN240
BGLY254
BTYR255
BVAL256
BHOH406
BHOH422

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 354
ChainResidue
BCYS139
BCYS142
BCYS164
BCYS175

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 B 1005
ChainResidue
BHIS66
BARG74
ELEU76
EALA77

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 B 1006
ChainResidue
BLYS31
BARG251
BHIS253
BHOH412
CASP12

site_idAC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 B 1011
ChainResidue
AARG106
BARG229
BARG230
BHOH399

site_idAC9
Number of Residues23
DetailsBINDING SITE FOR RESIDUE A2N C 1000
ChainResidue
CGLY50
CALA51
CGLY52
CTHR55
CASP61
CPHE62
CARG63
CTRP69
CGLN111
CHIS131
CLEU184
CGLY212
CTHR213
CSER214
CILE217
CASN238
CLEU239
CGLN240
CGLY254
CTYR255
CVAL256
CHOH383
CHOH403

site_idBC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 354
ChainResidue
CCYS139
CCYS142
CCYS164
CCYS175

site_idBC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 C 1003
ChainResidue
CASN222
CHOH422
CHOH512
CARG218
CPRO219

site_idBC3
Number of Residues20
DetailsBINDING SITE FOR RESIDUE A2N D 1000
ChainResidue
DGLY50
DALA51
DGLY52
DTHR55
DASP61
DPHE62
DARG63
DTRP69
DGLN111
DHIS131
DGLY212
DTHR213
DSER214
DILE217
DASN238
DLEU239
DGLN240
DGLY254
DTYR255
DVAL256

site_idBC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 354
ChainResidue
DCYS139
DCYS142
DCYS164
DARG176

site_idBC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 D 355
ChainResidue
DHIS66
DLYS79
DHOH377
DHOH386

site_idBC6
Number of Residues20
DetailsBINDING SITE FOR RESIDUE A2N E 1000
ChainResidue
BASP81
EGLY50
EALA51
EGLY52
ETHR55
EASP61
EPHE62
EARG63
ETRP69
EGLN111
EHIS131
EGLY212
ETHR213
ESER214
EASN238
ELEU239
EGLN240
EGLY254
ETYR255
EVAL256

site_idBC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN E 354
ChainResidue
ECYS139
ECYS142
ECYS164
ECYS175

site_idBC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 E 1002
ChainResidue
BHIS66
BLYS79
EHIS66
ELYS79

site_idBC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 E 1007
ChainResidue
EGLU27
ELYS31
EARG251
EHIS253

site_idCC1
Number of Residues1
DetailsBINDING SITE FOR RESIDUE SO4 E 1010
ChainResidue
EARG162

site_idCC2
Number of Residues19
DetailsBINDING SITE FOR RESIDUE A2N F 1000
ChainResidue
FGLY50
FALA51
FGLY52
FTHR55
FASP61
FPHE62
FARG63
FTRP69
FGLN111
FHIS131
FGLY212
FTHR213
FSER214
FASN238
FLEU239
FGLN240
FGLY254
FTYR255
FVAL256

site_idCC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN F 354
ChainResidue
FCYS139
FCYS142
FCYS164
FCYS175

site_idCC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 F 1001
ChainResidue
FTHR83
FPHE84
FGLU85
FVAL151
FHOH416

site_idCC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 F 1004
ChainResidue
FVAL151
FGLY153
FARG162

site_idCC6
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 F 1009
ChainResidue
FHIS66
FLYS79

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues54
DetailsCompositional bias: {"description":"Pro residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues6
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18337721","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23552949","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23892288","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27322069","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"28406396","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"21362626","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3K35","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZG6","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues66
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"23552949","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21362626","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3K35","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZG6","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues23
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21362626","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23552949","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27990725","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3K35","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PKI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PKJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZG6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MF6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MFP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MFZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MGN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues6
DetailsSite: {"description":"Formation of an covalent adduct with nitro-fatty acid activators","evidences":[{"source":"PubMed","id":"33122195","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues6
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"32538779","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues6
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"24043303","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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